Özet
Şener, M. The effect of inhaled corticosteroids on oral health in pre-school children, 2 to 6 years of age, with asthma. Hacettepe University, Faculty of Dentistry, Specialty Thesis in Pediatric Dentistry, Ankara, 2016. Asthma is a growing public health problem affecting over 300 million people worldwide. Although individuals from all age groups are affected by asthma, the disease usually begins in childhood. Depending on the increase in the prevalence of asthma, oral problems arising from the use of asthma medications have become a major health problem all over the world.
The children, aged 2 to 6 years, who referred to Hacettepe University Medical Faculty Allergy and Asthma Unit were included in this study. 115 children, who have been treated with inhaled corticosteroids for at least 6 months and did not have any other systemic health problems, were examined. After approval of the Local Ethics Committee of Hacettepe University, a questionnaire was conducted to the parents before oral examination. Written informed consents were obtained from the parents and the children were examined using dental mirror and probe under dental unit lighting after air-drying the teeth. Oral health status was evaluated with dmft-dmfs, DMFT-DMFS, ICDAS II, plaque index and gingival index. Furthermore posterior, anterior and canine occlusal relationships were also evaluated. The average duration of inhaler use in children was 19.84 ± 11.46 months. The use of budesonide+lactose inhaler resulted in higher prevalence of caries in permanent teeth than that of fluticasone propionate inhaler (p=0,046). Increased inhaled corticosteroids use was associated with high dmft-dmfs/DMFT-DMFS, plaque and gingival index without statistically difference (p>0,05). However, increased inhaled corticosteroid use was associated with oral candidiasis and it was statistically significant (p=0,027). As a result; inhaled corticosteroid is an important risk factor for tooth decay and gum disease. In addition, due to the effect of immunosuppression, increased usage of inhaled corticosteroid increases the risk of developing opportunistic pathogen candida. Families should be educated about the effects of asthma medications on oral health and should be encouraged for attending to regular dental visits. Also patients should be advised to rinse their mouths after inhaler use.
Künye
1. Thomas, M.S., Parolia, A., Kundabala, M.,Vikram, M. (2010) Asthma and oral health: a review. Australian Dental Journal, 55 (2), 128-133.
2. Bateman, E., Hurd, S., Barnes, P., Bousquet, J., Drazen, J., FitzGerald, M. ve diğerleri. (2008) Global strategy for asthma management and prevention: GINA executive summary. European Respiratory Journal, 31 (1), 143-178.
3. Waldman, H.B., Swerdloff, M.,Perlman, S.P. (1999) An increasing number of your pediatric patients may have asthma: the demographics of asthma. ASDC journal of dentistry for children, 67 (2), 98-101, 182.
4. Türk Toraks Derneği Astım Tanı ve Tedavi Rehberi. (2009) Türk Toraks Dergisi, 10, 6-75.
5. Ryberg, M., Möller, C.,Ericson, T. (1987) Effect of β2-adrenoceptor agonists on saliva proteins and dental caries in asthmatic children. Journal of dental research, 66 (8), 1404-1406.
6. Ersin, N.K., Guelen, F., Eronat, N., Cogulu, D., Demir, E., Tanac, R. ve diğerleri. (2006) Oral and dental manifestations of young asthmatics related to medication, severity and duration of condition. Pediatrics international, 48 (6), 549-554.
7. Shaw, L., Al-Dlaigan, Y.H.,Smith, A. (1999) Childhood asthma and dental erosion. ASDC journal of dentistry for children, 67 (2), 102-106, 182.
8. Stensson, M., WENDT, L.K., Koch, G., Oldaeus, G.,Birkhed, D. (2008) Oral health in preschool children with asthma. International Journal of Paediatric Dentistry, 18 (4), 243-250.
9. Hyyppä, T.M., Koivikko, A.,Paunio, K.U. (1979) Studies on periodontal conditions in asthmatic children. Acta Odontologica Scandinavica, 37 (1), 15-20.
10. Eloot, A., Vanobbergen, J., De Baets, F.,Martens, L. (2004) Oral health and habits in children with asthma related to severity and duration of condition. Eur J Paediatr Dent, 5 (4), 210-215.
11. Ellepola, A.,Samaranayake, L. (2001) Inhalational and topical steroids, and oral candidosis: a mini review. Oral diseases, 7 (4), 211-216.
12. Steinbacher, D.M.,Glick, M. (2001) The dental patient with asthma: an update and oral health considerations. The Journal of the American Dental Association, 132 (9), 1229-1239.
13. Stensson, M., WENDT, L.K., Koch, G., Nilsson, M., OLDAEUS, G.,Birkhed, D. (2010) Oral health in pre‐school children with asthma–followed from 3 to 6 years. International Journal of Paediatric Dentistry, 20 (3), 165-172.
14. Stensson, M., Wendt, L.-K., Koch, G., Oldaeus, G., Lingström, P.,Birkhed, D. (2010) Caries prevalence, caries-related factors and plaque pH in adolescents with long-term asthma. Caries research, 44 (6), 540-546.
15. Barnes, P., Godfrey S. (1997). Astım 3. Basım. London: Martin Dunitz Ltd.
16. Türktaş, H. (1998). Astma. İ. Türktaş, Türktaş H. (Ed.). Astma. Ankara: Bozkır Matbaacılık
17. Bateman, E.D., Hurd, S.S., Barnes, P.J., Bousquet, J., Drazen, J.M., FitzGerald, M. ve diğerleri. (2008) Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J, 31 (1), 143-178.
18. (GINA), G.I.f.A. (2008). Global strategy for asthma management and prevention. WHO/NHLBI workshop report. (Rapor No): National Institutes of Health.
19. Muro, S., Minshall, E.M.,Hamid, Q.A. (2000) The pathology of chronic asthma. Clinics in chest medicine, 21 (2), 225-244.
20. Toraks Derneği Astım Tanı ve Tedavi Rehberi Toraks Dergisi. (2009).
21. Tomaç, N., Saraçlar, Y. (2003) Astım epidemiyolojisi. Klinik Çocuk Forumu Pediatrik Alerji Özel Sayısı 2, 3(4), 6-16.
22. Tuncer, A. (1997) Çocukluk çağında bronşial astım tanısı ve ayırıcı tanısı. Katkı Pediatri Dergisi, 18(6), 712-723.
23. Asher, M., Keil, U., Anderson, H., Beasley, R., Crane, J., Martinez, F. ve diğerleri. (1995) International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. European respiratory journal, 8 (3), 483-491.
24. Miralles-Lopez, J., Guillen-Grima, F., Aguinaga-Ontoso, E., Aguinaga-Ontoso, I., Sanchez-Gascon,,F., N.-A., J. (1999) Broncial ashtma prevalence in childhood. Allergol Immunopathol, 27, 200-211.
25. Kurukulaaratchy, R., Fenn, M., Twiselton, R., Matthews, S.,Arshad, S. (2002) The prevalence of asthma and wheezing illnesses amongst 10-year-old schoolchildren. Respiratory medicine, 96 (3), 163-169.
26. Öneş, Ü., Sapan, N., Somer, A., Dişçi, R., Salman, N., Güler, N. ve diğerleri. (1997) Prevalence of childhood asthma in Istanbul, Turkey. Allergy, 52 (5), 570-575.
27. Çakır, M., Çetinkaya, F., Öztürk, F., Küçüködük, S., Saraçlar, Y. (1997). Samsun ilindeki çocuklarda astma bronsiale ve allerjik hastalıkların sıklığı. VII. Ulusal Allerji ve Klinik İmmünoloji Kongresi. Özet kitabı:15. Bursa
28. Bayram, İ., Güneser Kendirli, S., Altıntas, D., Yılmaz, M., Bingöl, G. (1998). Adana’da alerjik hastalıkların sıklığı. VIII. Ulusal Allerji ve Klinik İmmünoloji Kongresi, Özet kitabı: 2. Kuşadası
29. Yıldırım, M., Ergür, A., Tanzer, F., Saraçlar, Y., Tuncer, A. (1998). Sivas il merkezinde cocukluk çağı allerjik hastalıkların prevalansı. VIII. Ulusal Allerji ve Klinik İmmünoloji Kongresi, Özet kitabı: 18. Kuşadası
30. Saraclar, Y., Şekerel, B., Kalayci, Ö., Cetinkaya, F., Adalioǧlu, G., Tuncer, A. ve diğerleri. (1998) Prevalence of asthma symptoms in school children in Ankara, Turkey. Respiratory medicine, 92 (2), 203-207.
31. Bayram, İ., Kendİrlİ, S.G., YIlmaz, M., Alpaslan, N., Karakoç, G.B.,AltIntaŞ, D.U. (2001) Hatay'ın Payas Kasabasındaki Okul çağındaki çocuklarda alerjik hastalıkların prevalansı ve astımı etkileyen faktörler. Turkiye Klinikleri Journal of Allergy & Asthma, 3 (2), 56-65.
32. Barıs, D., Sahin, A., Coplu, L., Emri, S., Selcuk, Z.T., Savcı, S. (1996) Astmaya karsı 5000 yıllık çare arayışı. Kent Matbaacılık, 2. Baskı, 9-13.
33. Kuyucu, S., Kalaycı, O. (1997) Bronsiyal Astma İmmunopatolojisi. Katkı Pediatri Dergisi, 18 (697-705).
34. Nadel, J.A.,Busse, W.W. (1998) Asthma. Am J Respir Crit Care Med, 157 (4 Pt 2), S130-138.
35. Subbarao, P., Mandhane, P.J.,Sears, M.R. (2009) Asthma: epidemiology, etiology and risk factors. Canadian Medical Association Journal, 181 (9), E181-E190.
36. Global Strategy for Asthma Management and Prevention. (2007 (update)).
37. Stein, R.T., Sherrill, D., Morgan, W.J., Holberg, C.J., Halonen, M., Taussig, L.M. ve diğerleri. (1999) Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. The Lancet, 354 (9178), 541-545.
38. Shaheen, S., Barker, D., Heyes, C., Shiell, A., Aaby, P., Hall, A. ve diğerleri. (1996) Measles and atopy in Guinea-Bissau. The Lancet, 347 (9018), 1792-1796.
39. İnal,Karakoç, A., Bingöl, G. (2009) Çocukluk Çağı Astımı Gelişimindeki Risk Faktörleri. Turkiye Klinikleri Journal of Pediatrical Sciences, 5 (3), 22-32.
40. Solak, Z. (2003) Astım ve Atopi Gelişiminde Hijyen Hipotezi. Toraks Dergisi, 4(3), 269-278.
41. Joseph, C.L., Foxman, B., Leickly, F.E., Peterson, E.,Ownby, D. (1996) Prevalence of possible undiagnosed asthma and associated morbidity among urban schoolchildren. J Pediatr, 129 (5), 735-742.
42. Weis, S. (1995) Asthma Epidemiology risk factors and natural history in: Bierman CW.Peartman DS (eds). Allergy, asthma and immunology from infancy adulthood. 6th ed, 472-484.
43. Mahapatra, P. (1993) Social, economic and cultural aspects of asthma: an exploratory study in Andhra Pradesh, India. Institute of Health Systems.
44. Neffen, H., Fritscher, C., Cuevas Schacht, F., Levy, G., Chiarella, P., Soriano, J.B. ve diğerleri. (2005) Asthma control in Latin America: the asthma insights and reality in Latin America (AIRLA) survey. Revista Panamericana de Salud Pública, 17 (3), 191-197.
45. Erkan, L. (1991). Çocuklarda astma. İ. Barış (Ed.). Bronş Astması (s. 50-62). Ankara
46. Dağlı, E. (2003) Astım. Klinik Çocuk Forumu Çocuk Göğüs Hastalıkları Özel Sayısı, 3(1), 4-12.
47. William, W., Anthony, RH., Myron JL., Judith MS. (2003). Current Pediatric Diagnosis & Treatment 16 th edition.
48. Erkan, L. (1991) Çocuklarda asthma. Bronş asthması. 50-62.
49. Gemicioğlu, B. (2001) Bronş astımı. İstanbul İ. Ü. Yayınları, 4297, 621-658.
50. Zeyrek, D. (2006) Astım bronsiale tanılı çocuklarda IL-1β ve IL-1 reseptör antagonisti gen polimorfizmi. Yan dal uzmanlık tezi.
51. Georgen, P., Weiss, KB. (1995) Epidemiology of astma. Blackwell Scientific Publication, 15-28.
52. Ober, C.,Hoffjan, S. (2006) Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun, 7 (2), 95-100.
53. Wills-Karp, M.,Ewart, S.L. (2004) Time to draw breath: asthma-susceptibility genes are identified. Nat Rev Genet, 5 (5), 376-387.
54. Hoffjan, S.,Ober, C. (2002) Present status on the genetic studies of asthma. Curr Opin Immunol, 14 (6), 709-717.
55. Wolf, R. (2004) Essential Pediatric Allergy. Asthma and Immunology, 6, 59-79.
56. Holgate, S.T. (1997) The cellular and mediator basis of asthma in relation to natural history. Lancet, 350 Suppl 2, Sii5-9.
57. Ghosh, B., Sharma, S.,Nagarkatti, R. (2003) Genetics of asthma: current research paving the way for development of personalized drugs. Indian J Med Res, 117, 185-197.
58. Neyzi, O., Ertuğrul T. (2009) Bronşial astım ve hışıltılı çocuk. Pediyatri, 1, 726.
59. Pearce, N., Pekkanen, J.,Beasley, R. (1999) How much asthma is really attributable to atopy? Thorax, 54 (3), 268-272.
60. Liu, A., Covar, R., Spahn, J., Leung, D. (2007). Childhood Asthma. R. M. Kliegman, Behrman, R.E., Jenson, H.B., Stanton, B.F. (Ed.). Nelson Textbook of Pediatrics, 18th Edition (s. 953-970). Philadelphia: Saunders Elsevier
61. Bavbek, S., Anlar, YF., Kalaycı, Ö. (2000) Astım epidemiyolojisi ve risk faktörleri. Astımda immünopatolojik mekanizmalar. T Klin AlIerji-Astım, 2, 57-72.
62. Jaakkola, J.J.,Gissler, M. (2004) Maternal smoking in pregnancy, fetal development, and childhood asthma. Am J Public Health, 94 (1), 136-140.
63. Kelly, Y., Brabin, B., Milligan, P., Heaf, D., Reid, J.,Pearson, M. (1995) Maternal asthma, premature birth, and the risk of respiratory morbidity in schoolchildren in Merseyside. Thorax, 50 (5), 525-530.
64. Kramer, M. (1999) Maternal antigen avoidance during pregnancy for preventing atopic disease in infants of women at high risk. The Cochrane database of systematic reviews (2), CD000133-CD000133.
65. Nimmagadda, S.R.,Evans, R., 3rd. (1999) Allergy: etiology and epidemiology. Pediatr Rev, 20 (4), 111-115; quiz 116.
66. Nelson, D.A., Johnson, C.C., Divine, G.W., Strauchman, C., Joseph, C.L.,Ownby, D.R. (1997) Ethnic differences in the prevalence of asthma in middle class children. Ann Allergy Asthma Immunol, 78 (1), 21-26.
67. Sears, M.R., Holdaway, M.D., Flannery, E.M., Herbison, G.P.,Silva, P. (1996) Parental and neonatal risk factors for atopy, airway hyper-responsiveness, and asthma. Archives of disease in childhood, 75 (5), 392-398.
68. Steerenberg, P.A., Van Amsterdam, J.G., Vandebriel, R.J., Vos, J.G., Van Bree, L.,Van Loveren, H. (1999) Environmental and lifestyle factors may act in concert to increase the prevalence of respiratory allergy including asthma. Clin Exp Allergy, 29 (10), 1303-1308.
69. Duhme, H., Weiland, S., Rudolph, P., Wienke, A., Kramer, A.,Keil, U. (1998) Asthma and allergies among children in West and East Germany: a comparison between Munster and Greifswald using the ISAAC phase I protocol. International Study of Asthma and Allergies in Childhood. European Respiratory Journal, 11 (4), 840-847.
70. Jones, C.A., Holloway, J.A.,Warner, J.O. (2000) Does atopic disease start in foetal life? Allergy, 55 (1), 2-10.
71. Gdalevich, M., Mimouni, D.,Mimouni, M. (2001) Breast-feeding and the risk of bronchial asthma in childhood: a systematic review with meta-analysis of prospective studies. The Journal of pediatrics, 139 (2), 261-266.
72. Douglass, J., O'hehır, RE. (2000) What determines asthma phenotype? Am J Respir Crit Care Med, 161, 211-214.
73. Prescott, S., Macaubas, C., Holt, BJ., Smallacombe, TB., Loh, R., Sly, PD., Holt, PG. (1998) Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile. J Immunol, 160, 4730-4737.
74. Nolte, H., Backer, V.,Porsbjerg, C. (2001) Environmental factors as a cause for the increase in allergic disease. Ann Allergy Asthma Immunol, 87 (6 Suppl 3), 7-11.
75. Sarinho, E.S., Sarinho, S., Ferreira, O.S., Brito, W.P., Filho, A.S.,Cartaxo, C.G. (1995) [Risk factors for childhood asthma in Fernando de Noronha: a case control study]. J Pediatr (Rio J), 71 (5), 270-272.
76. Peat, J.K.,Li, J. (1999) Reversing the trend: reducing the prevalence of asthma. J Allergy Clin Immunol, 103 (1 Pt 1), 1-10.
77. Möller, C., Dreborg, S., Ferdousi, H.A., Halken, S., Høst, A., Jacobsen, L. ve diğerleri. (2002) Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). Journal of Allergy and Clinical Immunology, 109 (2), 251-256.
78. Holt, P.G., Macaubas, C., Prescott, S.L.,Sly, P.D. (1999) Microbial stimulation as an aetiologic factor in atopic disease. Allergy, 54 Suppl 49, 12-16.
79. Rabe, K.F., Vermeire, P.A., Soriano, J.B.,Maier, W.C. (2000) Clinical management of asthma in 1999: the Asthma Insights and Reality in Europe (AIRE) study. Eur Respir J, 16 (5), 802-807.
80. Becklake, M.R.,Ernst, P. (1997) Environmental factors. Lancet, 350 Suppl 2, Sii10-13.
81. Wiesch, D.G., Samet, J.M. (1998). Epidemiology and natural history of asthma. E. Middleton, Reed, C.E., Ellis, E.F., Yunginger, J.W., Busse, W.W. (Ed.). Alerji Principles and Practice (s. 799-815). USA: Mosby-Year Book
82. Bavbek, S., Anlar, YF., Kalaycı, Ö. (2000) Astım epidemiyolojisi ve risk faktörleri. t Klin AlIerji-Astım Dergisi, 2, 57-66.
83. Kalyoncu, A. (2001) Bronş astması. Atlas Kitapçılık.
84. Anderson, S.D., Daviskas, E.,Smith, C.M. (1989) Exercise-induced asthma: a difference in opinion regarding the stimulus. Allergy Proc, 10 (3), 215-226.
85. Pierson, W.E.,Voy, R.O. (1988) Exercise-induced bronchospasm in the XXIII summer Olympic games. N Engl Reg Allergy Proc, 9 (3), 209-213.
86. Karaman, Ö., Babayiğit, A., Ölmez, D. (2006) Çocukluk Çağında Astım. Güncel Pediatri, 3, 56-62.
87. Tuncer, A. (1997) Çocukluk Çağı Bronşial Astmada Tanı ve Ayırıcı Tanı. Katkı Pediatri Dergisi, 18(6), 712-723.
88. Tanaç, R. (2007) Çocukluk çağında astım tanısı. Güncel Çocuk Sağlığı, 1(2), 47-52.
89. Guidelines for the diagnosis and management of asthma: update on selected topics, 2002: National Asthma Education and Prevention Program, National Instutues of Health. (2002) J Allergy Clin Immunol, 141.
90. Global Initiative for Asthma. Global strategy for asthma management and prevention revised 2006. Medical Communications Resources, NIH publication. (2006).
91. Mos, H., Gern, JE., Lemanske, RF Jr. . (2003). Asthma in infancy and childhood. F. Atkinson, Yunginger, JW., Busse, WW., Bochner, BS., Holgate, St., Simsons, F., Hosne, A. (Ed.). Allergy, Principles & Practice, 6th edition. Mosby-Year Book (s. 1225-1255)
92. Cokugras, H., Akcakaya, N., Seckin, A., Camcioglu, Y., Sarimurat, N. (2001) Ultrastructural examination of bronchial biopsy specimens from children with moderate asthma. Thorax, 56(1), 25-29.
93. Martinez, F.D., Wright, A.L., Taussig, L.M., Holberg, C.J., Halonen, M.,Morgan, W.J. (1995) Asthma and wheezing in the first six years of life. New England Journal of Medicine, 332 (3), 133-138.
94. Martinez, F.D. (2002) Development of wheezing disorders and asthma in preschool children. Pediatrics, 109 (2 Suppl), 362-367.
95. Gemicioğlu, B. (2004). Atak kavramı ve tedavi yaklaşımı. B. Gemicioğlu (Ed.). Tanımdan tedaviye astım (s. 457-465). İstanbul: Turgut yayıncılık
96. Pascual, R., Jhonson, JJ., Peters, SP. (2008). Asthma: Clinical Presentation and Management. A. Fishman (Ed.). Fishman’s Pulmonary Diseases and Disorders (forth ed) (s. 815-836). New York: McGraw-Hill Book Company
97. Orhan, F., Karakaş, T. (2007) Diagnosis in Allergic Diseases. Türkiye Klinikleri J Pediatr Sci, 3 (9), 5-11.
98. Atkins, D., Leung, DYM. (2004). Diagnosis of Allergic Disease. R. Behrman, Kliegman, RM., Jenson, HM. (Ed.). Nelson Textbook of Pediatrics 17. Ed. (s. 747-751). WB Saunders, Philadelphia
99. Ownby, D. (2001) Skin tests in comparison with other diagnostic methods. Immunol Allergy Clin North Am, 21, 355-367.
100. Jaing, T.H., Yang, C.P., Hung, I.J., Chiu, C.H.,Chang, K.W. (2003) Efficacy of Helicobacter pylori eradication on platelet recovery in children with chronic idiopathic thrombocytopenic purpura. Acta Paediatr, 92 (10), 1153-1157.
101. Yıldırım, N., Akçakaya, N., Aydemir, E.H., Öz, F. (2001) Bronş astımı ve allerjik rinit. Allerjiler, 9-53, 91-104.
102. Weinberg, M. (2003) Clinical patterns and natural history of asthma. J Pediatr, 142, 15-20.
103. Busse, W., O’Bryne, PM., Holtage, ST. (2003). Asthma Patogenesis. N. Adkinson, Yunginger, JW., Busse, WW., Bochner, BS., Holtage, ST., R.Simsons, FE. (Ed.). Allergy principle and practice (s. 1175-1207). Philadelphia: Mosby
104. Kaliner, M. (1996). Pathogenesis of asthma. R. Rich (Ed.). Clinical immunology and practice (s. 909-923). Mosby
105. Türktas, H., Türktas, İ. (1998). Astma, 1. Baskı. (s. 27-47). Ankara: Bozkır Matbaacılık
106. To, T., Vydykhan, T.N., Dell, S., Tassoudji, M.,Harris, J.K. (2004) Is obesity associated with asthma in young children? J Pediatr, 144 (2), 162-168.
107. Kalaycı, Ö. (2000) Astımda immünopatolojik mekanizmalar. Türkiye Klinikleri Allerji-Astım Dergisi, 2, 67-72.
108. Peters, S., Zagrillis, G., Fish, JE. (1998). Late phase allergic reaction. E. Middleton, Reed, CE., Ellis, EF. (Ed.). Allergy, Principles and Practice. (s. 342-355). St.Louis: Mosby-Year Book
109. Leung, Y.M. (2004). Allergic disorders. R. E. Behrman, Kliegman, R.M., Jenson, H.B. (Ed.). Nelson Textbook of Pediatrics, 17 th edition (c. 130, s. 743-792). Philadelphia: WB Saunders Comp
110. Takizawa, H. (2008) Remodeling in small airways of asthma. Respiratory Medicine CME, 1 (2), 69-74.
111. Demir, E.,Midyat, L. (2009) Astım Patogenezi. Turkiye Klinikleri Journal of Pediatrical Sciences, 5 (3), 6-16.
112. James, A. (2005) Airway remodeling in asthma. Current opinion in pulmonary medicine, 11 (1), 1-6.
113. Vignola, A.M., Mirabella, F., Costanzo, G., Di Giorgi, R., Gjomarkaj, M., Bellia, V. ve diğerleri. (2003) Airway remodeling in asthma. CHEST Journal, 123 (3_suppl), 417S-422S.
114. Georgen, P.J., Weiss, K.B. (1995). Epidemiology of astma. W. W. Busse, Holgate, S.T. (Ed.). Asthma and Rhinitis (s. 15-28). USA: Blackwell Scientific Publication
115. Türktaş, H. (1996). Astım Patogenezi. (s. 95-106). Ankara: Bozkır matbaası
116. Murphy, S. (1993). Asthma an inflammatory disease. B. Hillman (Ed.). Pediatric respiratory disease (s. 621-627). Philadelphia: WB Saunders
117. Ricci, M., Matucci, A.,Rossi, O. (1994) Cellular and molecular basis of airway allergic inflammation. Allergol Immunopathol (Madr), 22 (4), 184-189.
118. O'Byrne, P.M.,Inman, M.D. (2003) Airway hyperresponsiveness. Chest, 123 (3 Suppl), 411s-416s.
119. Simons, F.E. (1999) Inhaled glucocorticoids in children: A favourable therapeutic index. Can Respir J, 6 (2), 175-178.
120. Skoner, D.P. (2002) Balancing safety and efficacy in pediatric asthma management. Pediatrics, 109 (2 Suppl), 381-392.
121. Kercsmar, C.M. (2003) Current trends in management of pediatric asthma. Respir Care, 48 (3), 194-205; discussion 205-198.
122. Rottier, B.L.,Duiverman, E.J. (2009) Anti-inflammatory drug therapy in asthma. Paediatr Respir Rev, 10 (4), 214-219.
123. Irwin, R.S.,Richardson, N.D. (2006) Side effects with inhaled corticosteroids: the physician's perception. Chest, 130 (1 Suppl), 41s-53s.
124. Canbakan, S.,Çapan, N. (2000) Astımda Kronik Tedavi. Turkiye Klinikleri Journal of Allergy & Asthma, 2 (2), 90-96.
125. Şekerel, B.E. (1999) Çocukluk çağı astımının uzun süreli tedavisi. Çocuk Forumu, 2 (3), 39-42.
126. Gordon, A.C., McDonald, C.F., Thomson, S.A., Frame, M.H., Pottage, A.,Crompton, G.K. (1987) Dose of inhaled budesonide required to produce clinical suppression of plasma cortisol. Eur J Respir Dis, 71 (1), 10-14.
127. Dağlı, E. (2009) Astım Tedavisi. Turkiye Klinikleri J Pediatr Sci, 5 (3), 67-72.
128. Leung, Y.M. (2007). Allergic disorders. R. E. Behrman, Kliegman, R.M., Jenson, H.B. (Ed.). Nelson Textbook of Pediatrics, 18 th edition (c. 139, s. 935-938). Philadelphia: WB Saunders Comp
129. Amin, N. (2001). Childhood asthma: management and prevention. A. J. Dozor (Ed.). Primary Pediatric Pulmonology (c. 8, s. 137-162). New York: Futura Publishing Company
130. Robinson, P.D.,Van Asperen, P. (2009) Asthma in childhood. Pediatr Clin North Am, 56 (1), 191-226, xii.
131. Canbakan, S., Çapan, N. . (2000) Astımda kronik tedavi. T Klin Alerji-Astım, 2, 90-96.
132. Kaditis, A.G., Winnie, G.,Syrogiannopoulos, G.A. (2007) Anti-inflammatory pharmacotherapy for wheezing in preschool children. Pediatr Pulmonol, 42 (5), 407-420.
133. Zanchi, N.E., Felitti, V., Nicastro, H., Lorenzeti, F.M.,Lancha, A.H. (2010) Glucocorticoids: extensive physiological actions modulated through multiple mechanisms of gene regulation. Journal of cellular physiology, 224 (2), 311-315.
134. Tamaoki, J., Chiyotani, A., Tagaya, E., Sakai, N.,Konno, K. (1994) Effect of long term treatment with oxitropium bromide on airway secretion in chronic bronchitis and diffuse panbronchiolitis. Thorax, 49 (6), 545-548.
135. McDerra, E.J., Pollard, M.A.,Curzon, M.E. (1998) The dental status of asthmatic British school children. Pediatr Dent, 20 (4), 281-287.
136. Reddy, D.K., Hegde, A.M.,Munshi, A.K. (2003) Dental caries status of children with bronchial asthma. J Clin Pediatr Dent, 27 (3), 293-295.
137. Johansson, I.,Ericson, T. (1987) Saliva composition and caries development during protein deficiency and beta-receptor stimulation or inhibition. J Oral Pathol, 16 (3), 145-149.
138. de Almeida Pdel, V., Gregio, A.M., Machado, M.A., de Lima, A.A.,Azevedo, L.R. (2008) Saliva composition and functions: a comprehensive review. J Contemp Dent Pract, 9 (3), 72-80.
139. Kenny, D.J.,Somaya, P. (1989) Sugar load of oral liquid medications on chronically ill children. J Can Dent Assoc, 55 (1), 43-46.
140. Shashikiran, N., Reddy, V.,Raju, P.K. (2007) Effect of antiasthmatic medication on dental disease: dental caries and periodontal disease. Journal of Indian Society of Pedodontics and Preventive Dentistry, 25 (2), 65.
141. Ryberg, M., Möller, G.,Erigson, T. (1991) Saliva composition and caries development in asthmatic patients treated with β2‐adrenoceptor agonists: a 4‐year follow‐up study. European Journal of Oral Sciences, 99 (3), 212-218.
142. Milano, M., Lee, J.Y., Donovan, K.,Chen, J.-W. (2006) A cross-sectional study of medication-related factors and caries experience in asthmatic children. Pediatric dentistry, 28 (5), 415-419.
143. Bjerkeborn, K., Dahllof, G., Hedlin, G., Lindell, M.,Modeer, T. (1987) Effect of disease severity and pharmacotherapy of asthma on oral health in asthmatic children. European Journal of Oral Sciences, 95 (2), 159-164.
144. Meldrum, A., Thomson, W., Drummond, B.,Sears, M. (2001) Is asthma a risk factor for dental caries? Findings from a cohort study. Caries research, 35 (4), 235-239.
145. Mortimer, K.J., Harrison, T.W.,Tattersfield, A.E. (2005) Effects of inhaled corticosteroids on bone. Ann Allergy Asthma Immunol, 94 (1), 15-21; quiz 22-13, 79.
146. Hanania, N.A., Chapman, K.R., Sturtridge, W.C., Szalai, J.P.,Kesten, S. (1995) Dose-related decrease in bone density among asthmatic patients treated with inhaled corticosteroids. Journal of allergy and clinical immunology, 96 (5), 571-579.
147. Wactawski-Wende, J. (2001) Periodontal diseases and osteoporosis: association and mechanisms. Annals of periodontology, 6 (1), 197-208.
148. Han, E.-R., Choi, I.S., Kim, H.-K., Kang, Y.-W., Park, J.-G., Lim, J.-R. ve diğerleri. (2009) Inhaled corticosteroid-related tooth problems in asthmatics. Journal of Asthma, 46 (2), 160-164.
149. Al‐Dlaigan, Y., Shaw, L.,Smith, A. (2002) Is there a relationship between asthma and dental erosion? A case control study. International Journal of Paediatric Dentistry, 12 (3), 189-200.
150. Sivasitamparam, K., Young, W., Jirattanasopa, V., Priest, J., Khan, F., Harbrow, D. ve diğerleri. (2002) Dental erosion in asthma: A case‐control study from south east Queensland. Australian dental journal, 47 (4), 298-303.
151. Tootla, R., Toumba, K.,Duggal, M. (2004) An evaluation of the acidogenic potential of asthma inhalers. Archives of oral biology, 49 (4), 275-283.
152. O'Sullivan, E.A.,Curzon, M.E. (1998) Drug treatments for asthma may cause erosive tooth damage. Bmj, 317 (7161), 820.
153. Kargul, B., Tanboga, I., Ergeneli, S., Karakoc, F.,Dagli, E. (1997) Inhaler medicament effects on saliva and plaque pH in asthmatic children. The Journal of clinical pediatric dentistry, 22 (2), 137-140.
154. Harding, S.M. (2001) Gastroesophageal reflux, asthma, and mechanisms of interaction. Am J Med, 111 Suppl 8A, 8s-12s.
155. Mansfield, L.,Stein, M. (1978) Gastroesophageal reflux and asthma: a possible reflex mechanism. Annals of allergy, 41 (4), 224.
156. Shaw, L., al-Dlaigan, Y.H.,Smith, A. (2000) Childhood asthma and dental erosion. ASDC J Dent Child, 67 (2), 102-106, 182.
157. Dugmore, C.R.,Rock, W.P. (2003) Asthma and tooth erosion. Is there an association? Int J Paediatr Dent, 13 (6), 417-424.
158. Kurt, E., Yildirim, H., Kiraz, N., Orman, A., Metintas, M., Akgun, Y. ve diğerleri. (2008) Oropharyngeal candidiasis with dry-powdered fluticasone propionate: 500 microg/day versus 200 microg/day. Allergol Immunopathol (Madr), 36 (1), 17-20.
159. Fukushima, C., Matsuse, H., Saeki, S., Kawano, T., Machida, I., Kondo, Y. ve diğerleri. (2005) Salivary IgA and oral candidiasis in asthmatic patients treated with inhaled corticosteroid. Journal of Asthma, 42 (7), 601-604.
160. Knight, L.,Fletcher, J. (1971) Growth of Candida albicans in saliva: stimulation by glucose associated with antibiotics, corticosteroids, and diabetes mellitus. J Infect Dis, 123 (4), 371-377.
161. Selroos, O., Backman, R., Forsen, K.O., Lofroos, A.B., Niemisto, M., Pietinalho, A. ve diğerleri. (1994) Local side-effects during 4-year treatment with inhaled corticosteroids--a comparison between pressurized metered-dose inhalers and Turbuhaler. Allergy, 49 (10), 888-890.
162. Erk, M. (2002) İnhalasyon teknikleri. Toraks Dergisi 3,7-13.
163. Salzman, G.A.,Pyszczynski, D.R. (1988) Oropharyngeal candidiasis in patients treated with beclomethasone dipropionate delivered by metered-dose inhaler alone and with Aerochamber. J Allergy Clin Immunol, 81 (2), 424-428.
164. Kumar, S.,Nandlal, B. (2012) Effects of Asthma and Inhalation corticosteroids on the dental arch morphology in children. Journal of Indian Society of Pedodontics and Preventive Dentistry, 30 (3), 242.
165. Bousquet, J., Khaltaev, N., Cruz, A., Denburg, J., Fokkens, W., Togias, A. ve diğerleri. (2008) Allergic rhinitis and its impact on asthma (ARIA) 2008. Allergy, 63 (s86), 8-160.
166. Barfield, W.D. (2011) Standard terminology for fetal, infant, and perinatal deaths. Pediatrics, 128 (1), 177-181.
167. Engle, W.A. (2006). A recommendation for the definition of “late preterm”(near-term) and the birth weight–gestational age classification system [Bildiri].Seminars in perinatology.
168. Fleischman, A.R., Oinuma, M.,Clark, S.L. (2010) Rethinking the definition of “term pregnancy”. Obstetrics & Gynecology, 116 (1), 136-139.
169. Haerian-Ardakani, A., Eslami, Z., Rashidi-Meibodi, F., Haerian, A., Dallalnejad, P., Shekari, M. ve diğerleri. (2014) Relationship between maternal periodontal disease and low birth weight babies.
170. Behrman, R.E., Kliegman, R.,Jenson, H.B. (2000). Nelson Textbook of Pediatrics (16 bs., c. 93). Berlin, Germany: W.B.Saunders
171. Ferguson, D.J. (2008). Growth of the Face and Dental Arches. R. E. McDonald, Arvey, D.R., Dean, J.A. (Ed.). Mcdonald And Avery’s Dentistry For the Child And Adolescent (s. 517-532). Missouri: Elsevier
172. Ismail, A., Sohn, W., Tellez, M., Amaya, A., Sen, A., Hasson, H. ve diğerleri. (2007) The International Caries Detection and Assessment System (ICDAS): an integrated system for measuring dental caries. Community dentistry and oral epidemiology, 35 (3), 170-178.
173. Monse, B., Heinrich‐Weltzien, R., Benzian, H., Holmgren, C.,van Palenstein Helderman, W. (2010) PUFA–An index of clinical consequences of untreated dental caries. Community dentistry and oral epidemiology, 38 (1), 77-82.
174. Silness, J.,Löe, H. (1964) Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta odontologica scandinavica, 22 (1), 121-135.
175. Löe, H. (1967) The gingival index, the plaque index and the retention index systems. Journal of periodontology, 38 (6), 610-616.
176. Organization, W.H. (2013). Oral Health Surveys Basic Methods 5th edition.
177. Moyers, R.E. (1988). Analysis of dentition and occlusion. R. E. Moyers (Ed.). Handbook of orthodontics 4th ed. Chicago: Year Book Medical
178. Angle, E.H. (1899) Classification of malocclusion.
179. Mannino, D.M., Homa, D.M., Pertowski, C.A., Ashizawa, A., Nixon, L.L., Johnson, C.A. ve diğerleri. (1998) Surveillance for asthma—United States, 1960–1995. MMWR CDC Surveill Summ, 47 (1), 1-27.
180. Gupta, R.S.,Weiss, K.B. (2009) The 2007 National Asthma Education and Prevention Program asthma guidelines: accelerating their implementation and facilitating their impact on children with asthma. Pediatrics, 123 (Supplement 3), S193-S198.
181. Martinez, F.D. (1999) Recognizing early asthma. Allergy, 54 Suppl 49, 24-28.
182. Mazzoleni, S., Stellini, E., Cavaleri, E., Angelova Volponi, A., Ferro, R.,Fochesato Colombani, S. (2008) Dental caries in children with asthma undergoing treatment with short-acting ß2-agonists. Eur J Paediatr Dent, 9 (3), 132-138.
183. Khalifa, M.A.A.A., Abouelkheir, H.M., Khodiar, S.E.-F.,Mohamed, G.A.M. (2014) Salivary composition and dental caries among children controlled asthmatics. Egyptian Journal of Chest Diseases and Tuberculosis, 63 (4), 777-788.
184. Slabšinskienė, E., Milčiuvienė, S., Narbutaitė, J., Vasiliauskienė, I., Andruškevičienė, V., Bendoraitienė, E. ve diğerleri. (2010) Severe early childhood caries and behavioral risk factors among 3-year-old children in Lithuania. Medicina (Kaunas), 46 (2), 135-141.
185. Ter Pelkwijk, A., van Palenstein Helderman, W.,Van Dijk, J. (1990) Caries experience in the deciduous dentition as predictor for caries in the permanent dentition. Caries research, 24 (1), 65-71.
186. Pitts, N.,Fyffe, H. (1988) The effect of varying diagnostic thresholds upon clinical caries data for a low prevalence group. Journal of dental research, 67 (3), 592-596.
187. Pitts, N. (2004) " ICDAS"--an international system for caries detection and assessment being developed to facilitate caries epidemiology, research and appropriate clinical management. Community dental health, 21 (3), 193.
188. Bagińska, J., Rodakowska, E., Wilczyńska-Borawska, M.,Jamiołkowski, J. (2013) Index of clinical consequences of untreated dental caries (pufa) in primary dentition of children from north-east Poland. Advances in medical sciences, 58 (2), 442-447.
189. Figueiredo, M., De Amorim, R., Leal, S., Mulder, J.,Frencken, J. (2011) Prevalence and severity of clinical consequences of untreated dentine carious lesions in children from a deprived area of Brazil. Caries research, 45 (5), 435-442.
190. Brigic, A., Kobaslija, S.,Zukanovic, A. (2015) Antiasthmatic Inhaled Medications as Favoring Factors for Increased Concentration of Streptococcus Mutans. Materia socio-medica, 27 (4), 237.
191. Lindemeyer, R.G., Satpute, N.S.,Katz, S.H. (2012) Evaluation of bronchial asthma as risk factor for early childhood caries. The Journal of the Michigan Dental Association, 94 (5), 46-49.
192. Shulman, J., Taylor, S.,Nunn, M. (2001) The association between asthma and dental caries in children and adolescents: a population–based case–control study. Caries research, 35 (4), 240-246.
193. Karl, L. (2002) Hakamima. Asthma and oral health. A clinical and epidemiological study. Acta Electronica Universitatis Tamperensis, 193.
194. Hyyppä, T. (1984) Gingival IgE and histamine concentrations in patients with asthma and in patients with periodontitis. Journal of clinical periodontology, 11 (2), 132-137.
195. Wotman, S., Mercadante, J., Mandel, I.D., Goldman, R.S.,Denning, C. (1973) The occurrence of calculus in normal children, children with cystic fibrosis, and children with asthma. Journal of periodontology, 44 (5), 278-280.
196. Lenander-Lumikari, M., Laurikainen, K., Kuusisto, P.,Vilja, P. (1998) Stimulated salivary flow rate and composition in asthmatic and non-asthmatic adults. Archives of oral biology, 43 (2), 151-156.
197. Mandel, I.D., Eriv, A., Kutscher, A., Denning, C., Thompson, R.H., Kessler, W. ve diğerleri. (1969) Calcium and Phosphorus Levels in Submaxillary Saliva Changes in Cystic Fibrosis and in Asthma. Clinical Pediatrics, 8 (3), 161-164.
198. Ehsani, S., Moin, M., Meighani, G., Pourhashemi, S.J., Khayatpisheh, H.,Yarahmadi, N. (2013) Oral health status in preschool asthmatic children in Iran. Iranian Journal of Allergy, Asthma and Immunology, 12 (3), 254.
199. Wogelius, P., Poulsen, S.,Sørensen, H.T. (2004) Use of asthma-drugs and risk of dental caries among 5 to 7 year old Danish children: a cohort study. Community dental health, 21 (3), 207-211.
200. Wogelius, P., Haubek, D., Nechifor, A., Nørgaard, M., Tvedebrink, T.,Poulsen, S. (2010) Association between use of asthma drugs and prevalence of demarcated opacities in permanent first molars in 6‐to‐8‐year‐old Danish children. Community dentistry and oral epidemiology, 38 (2), 145-151.
201. Kankaala, T.M., Virtanen, J.I.,Larmas, M.A. (1998) Timing of first fillings in the primary dentition and permanent first molars of asthmatic children. Acta Odontologica Scandinavica, 56 (1), 20-24.
202. Arnrup, K., Lundin, S.,Dahllöf, G. (1992) Analysis of paediatric dental services provided at a regional hospital in Sweden. Dental treatment need in medically compromised children referred for dental consultation. Swedish dental journal, 17 (6), 255-259.
203. Anjomshoaa, I., Cooper, M.E.,Vieira, A.R. (2009) Caries is associated with asthma and epilepsy. European journal of dentistry, 3 (4), 297.
204. Khalilzadeh, S., Salamzadeh, J., Salem, F., Salem, K.,Vala, M.H. (2007) Dental caries-associated microorganisms in asthmatic children. Tanaffos, 6 (4), 42-46.
205. Imhof, E., Elsasser, S., Karrer, W., Grossenbacher, M., Emmons, R.,Perruchoud, A. (1993) Comparison of Bronchodilator Effects of Fenoterol/lpratropium Bromide and Salbutamol in Patients with Chronic Obstructive Lung Disease. Respiration, 60 (2), 84-88.
206. Locker, D. (1993) Measuring social inequality in dental health services research: individual, household and area-based measures. Community dental health, 10 (2), 139-150.
207. Samec, T., Amaechi, B.T., Battelino, T., KRIVEC, U.,Jan, J. (2013) Influence of anti‐asthmatic medications on dental caries in children in Slovenia. International Journal of Paediatric Dentistry, 23 (3), 188-196.
208. Venetikidou, A. (1992) Incidence of malocclusion in asthmatic children. The Journal of clinical pediatric dentistry, 17 (2), 89-94.
209. Leone, F.T., Fish, J.E., Szefler, S.J.,West, S.L. (2003) Systematic review of the evidence regarding potential complications of inhaled corticosteroid use in asthma: collaboration of American College of Chest Physicians, American Academy of Allergy, Asthma, and Immunology, and American College of Allergy, Asthma, and Immunology. CHEST Journal, 124 (6), 2329-2340.
210. Richy, F., Bousquet, J., Ehrlich, G.E., Meunier, P.J., Israel, E., Morii, H. ve diğerleri. (2003) Inhaled corticosteroids effects on bone in asthmatic and COPD patients: a quantitative systematic review. Osteoporosis international, 14 (3), 179-190.
211. Doull, I., Freezer, N.J.,Holgate, S.T. (1995) Growth of prepubertal children with mild asthma treated with inhaled beclomethasone dipropionate. American journal of respiratory and critical care medicine, 151 (6), 1715-1719.
212. Verberne, A.A., Frost, C., Roorda, R.J., van der Laag, H.,Kerrebijn, K.F. (1997) One year treatment with salmeterol compared with beclomethasone in children with asthma. American Journal of Respiratory and Critical Care Medicine, 156 (3), 688-695.
213. Tse, S.M., Kelly, H.W., Litonjua, A.A., Van Natta, M.L., Weiss, S.T., Tantisira, K.G. ve diğerleri. (2012) Corticosteroid use and bone mineral accretion in children with asthma: effect modification by vitamin D. Journal of Allergy and Clinical Immunology, 130 (1), 53-60. e54.
214. Lipworth, B.J. (1993) Clinical pharmacology of corticosteroids in bronchial asthma. Pharmacology & therapeutics, 58 (2), 173-209.
215. Enwonwu, C.O., Meeks, V.I.,Sawiris, P.G. (1996) Elevated cortisol levels in whole saliva in HIV infected individuals. European journal of oral sciences, 104 (3), 322-324.
216. Samaranayake, L.P.,MacFarlane, T.W. (1985) On the role of dietary carbohydrates in the pathogenesis of oral candidosis. FEMS microbiology letters, 27 (1), 1-5.
217. Kuna, P. (1998) Long-term effects of steroid therapy. Wiad Lek, 51, 12-18.
218. Osler, W. ( 1892). Bronchial asthma. The principles and practise of medicine. (s. 497-501). Appleton, New York
219. Sontag, S.J., O'connell, S., Khandelwal, S., Miller, T., Nemchausky, B., Schnell, T.G. ve diğerleri. (1990) Most asthmatics have gastroesophageal reflux with or without bronchodilator therapy. Gastroenterology, 99 (3), 613-620.
220. Faubion, W.A.,Zein, N.N. (1998). Gastroesophageal reflux in infants and children [Bildiri].Mayo Clinic Proceedings.
221. Parsons, J.P.,Mastronarde, J.G. (2010) Gastroesophageal reflux disease and asthma. Current opinion in pulmonary medicine, 16 (1), 60-63.
222. Smith, J.,Woodcock, A. (2008) New developments in the objective assessment of cough. Lung, 186 (1), 48-54.
223. Thakkar, K., Boatright, R.O., Gilger, M.A.,El-Serag, H.B. (2010) Gastroesophageal reflux and asthma in children: a systematic review. Pediatrics, 125 (4), e925-e930.
224. Hashemipour, M., Zareei, M., Farokh, G.E.,Dastbous, A. (2008) Study of the relations between inflammatory condition of geographic tongue and allergy.