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Farmasötik Preparatlardan ve Gıdalardan Tobramisin Tayini İçin Moleküler Baskılanmış Nanosensörlerin Geliştirilmesi
(Sağlık Bilimleri Enstitüsü, 2013)
In this thesis study, the molecularly imprinted glassy carbon and quartz crystal microbalance (QCM) nanosensors were developed for the determination of tobramycin. For QCM nanosensor, firstly the modification of gold surface ...
Karaciğer ve Meme Kanseri Hücreleri ile Embriyonik Böbrek Hücrelerinde Doksorubisinin Apoptotik Genlerin ve Mdr-1 Geninin Ekspresyon Düzeylerine Etkisi
(Sağlık Bilimleri Enstitüsü, 2013)
In this study, in order to investigate roles of certain genes and expression levels of these genes in apoptosis, MCF-7 (breast), HEPG2 (liver) cancer cells and HEK293 embryonic kidney cells were treated with increasing ...
Development and Validation of an Ultra-Performance Liquid Chromatographic-Tandem Mass Spectrometry (Uplc-Ms/Ms) Method for Determination of Betamethasone or Dexamethasone in Pharmaceutical Preparations
(Sağlık Bilimleri Enstitüsü, 2013)
Development and Validation of an Ultra-Performance Liquid Chromatographic-Tandem Mass Spectrometry (UPLC-MS/MS) Method for Determination of Betamethasone or Dexamethasone in Pharmaceutical Preparations, Hacettepe University, ...
Metastatik Meme Kanseri Hücrelerinde Mtor Üzerine Etkili Bazı Mekanizmaların Araştırılması
(Sağlık Bilimleri Enstitüsü, 2013)
Signal trunsduction pathways play crucial roles in breast cancer pathogenesis. mTOR, which plays a central role in cell proliferation and interacts with several cell components, is selected as a target in MDA-MB- 231 ...
Ht29 Ve K562 Kanser Hücrelerinde Protein ve Metabolitlerin Analizi Için Çeşitli Analitik Yöntemlerin Geliştirilmesi
(Sağlık Bilimleri Enstitüsü, 2013)
Cancer is one of the most dangerous fatal diseases threating the human being both economically and socially. Therefore, the studies are performed on molecular level to understand cancer on molecular level and prevent the ...
Leflunomid In Farmasötik Preparatlardan Analizi Için Kapiler Elektroforez Yöntemi Geliştirilmesi ve Validasyonu
(Sağlık Bilimleri Enstitüsü, 2013)
In this study, a new micellar electrokinetic capillary chromatography
(MEKC) method was developed to analysis of Leflunomide in pharmaceutical
preparations. Best results in the MEKC method were obtained by the use of pH ...
Lökosit Miyeloperoksidaz Enziminin Saflaştırılması, Kinetik Özellikleri ile Reaktif Türlerin Oluşumundaki Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2013)
Myeloperoxidase (MPO) has been purified from human leucocytes obtained by leukapheresis, and kinetic properties were determined, nitrite oxidation and tyrosine nitration catalyzed by the purified enzyme have been studied. ...
Nnav1.5 Sodyum Kanalı ve Noç-4 Reseptör Sinyalinin Baskılanmasının İnsan Meme Kanseri Hücrelerinde Çoğalma ve Metastatik Potansiye Üzerine Etkisinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2013)
The incidence of breast cancer is rapidly increasing and it is one of the major causes of death. The molecular changes leading to malignant transformation and metastasis of mammary cells is studied intensively. The expression ...
In Cellulo Examination Of A Beta-Alpha Hybrid Construct Of Beta-Hexosaminidase A Subunits, Reported To Interact With The Gm2 Activator Protein And Hydrolyze Gm2 Ganglioside
(2013)
The hydrolysis in lysosomes of GM2 ganglioside to GM3 ganglioside requires the correct synthesis, intracellular assembly and transport of three separate gene products; i.e., the alpha and beta subunits of heterodimeric ...
Activation and Regioselectivity of Five-Membered Cyclic Thionocarbamates to Nucleophilic Attack
(Royal Soc Chemistry, 2013)
The cyclic thionocarbamate of alaninol undergoes nucleophilic attack by sulfur nucleophiles at 5-C to give 1-thiopropyl-2-amine derivatives when derivatised on nitrogen with a Boc group. Iodide under microwave conditions ...