Yayın tarihi için Temel Eczacılık Bilimleri Bölümü listeleme
Toplam kayıt 189, listelenen: 61-80
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The in Vitro and in Vivo Effects of Telomerase Substrate 6-Thio-2 -Deoxyguanosine
(Sağlık Bilimleri Enstitüsü, 2014)Telomerase mediated telomere targeted therapy represents a new approach in cancer therapy. In this study, I report that the nucleoside analogue 6-thio-2’-deoxyguanosine (6-thio-dG) is recognized by the telomerase ... -
Synthesis of New 2-(N'-Allylidene-Hydrazino) Quinazolinones and 2-(4,5-Dihydropyrazolyl)-Quinazolinones and Their Antimicrobial and Antifungal Activity Screening
(Asian Journal Of Chemistry, 2014)Novel 2-[N'-(1,3-disubstituted-phenyl) allylidene] hydrazine-3-ethyl-3H-quinazolin-4-one (8) and 2-(3,5-disubstituted-phenyl-4,5-dihydropyrazol- 1-yl)-3-ethyl-3H-quinazolin-4-one (9) compounds have been prepared and tested ... -
Uv Spectrophotometric Method For Determination Of The Dissolution Profile Of Rivaroxaban
(Dissolution Technologies, Inc, 2014)Rivaroxaban is an oral anticoagulant that is the first available orally active direct Factor Xa inhibitor. In this study, a UV spectrophotometric method was developed for the determination of rivaroxaban content in ... -
Capillary Electrophoresis For Total Glycosaminoglycan Analysis
(Springer Heidelberg, 2014)A capillary zone electrophoresis-laser-induced fluorescence detection (CZE-LIF) method was developed for the simultaneous analysis of disaccharides derived from heparan sulfate, chondroitin sulfate/dermatan sulfate, ... -
Caffeic Acid Phenethyl Ester As a Protective Agent Against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review
(2014)Caffeic acid phenethyl ester (CAPE), an active component of propolis, has been attracting the attention of different medical and pharmaceutical disciplines in recent years because of its antioxidant, anti-inflammatory, ... -
Organik Stereokimya
(Hacettepe Üniversitesi Yayınları, 2014)Stereokimya, farklı bir bilim değil kimya biliminin bir alt alanıdır. Bu alan organik kimya kitaplarında oldukça uygun bir biçimde ayrı bir bölüm olarak bulunmaktadır. Stereokimya, organik kimya içinden doğduğu ve organik ... -
Kimyasal Olarak İndüklenmiş Meme Kanseri Modelinde Klorofilin-Cu Kompleksinin Antioksidan Etkinliğinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2015)Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Investigation show that glutathione and related enzymes are often overexpressed in tumor cells ... -
Serotoninin Renal Hasardaki Rolü
(Sağlık Bilimleri Enstitüsü, 2015)In various acute and chronic renal diseases, tissue damage occurs and platelet activation is observed. Recent studies suggest that some factors released from activated platelets may participate in inflammation and fibrosis ... -
Alzheimer Hastalığı Tedavisinde Kullanılmak Üzere Donepezil Yüklü Plga-B-Peg Nanopartiküllerinin Hazırlanması ve Beyne Hedeflendirilmesi
(Sağlık Bilimleri Enstitüsü, 2015)Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disease, which is caused by irreversible loss of neurons in the hippocampus and cortex regions of the brain. Although the molecular mechanism ... -
İnsan Serum Bütirilkolinesterazının Karaciğer Hepg2 Hücrelerinde Lipid Metabolizması ile Etkileşiminin İncelenmesi.
(Sağlık Bilimleri Enstitüsü, 2015)Butyrylcholinesterase (BChE) synthesized in liver is mostly associated with the detoxification of xenobiotics. Recently we have shown that in sedentary young males, application of exercise and/or conjugated linoleic acid ... -
Evaluation Of A Capillary Electrophoresis Method For Routine Determination Of Varenicline Tartrate In Quality-Control Laboratories
(Soc Chemists Technologists Madeconia, 2015)In this study, analyses were carried out on a fused-silica capillary (i.d. 50.0 mu m, total length 48.5 cm, and effective length 40.0 cm) in normal mode by applying a voltage of 20 kV. Sample injections were made in ... -
Modulation Of Mitochondrial Complex I Activity Averts Cognitive Decline In Multiple Animal Models Of Familial Alzheimer'S Disease
(2015)Development of therapeutic strategies to prevent Alzheimer's disease (AD) is of great importance. We show that mild inhibition of mitochondrial complex I with small molecule CP2 reduces levels of amyloid beta and phospho-Tau ... -
Plasma 8-Isopgf2 Alpha and Serum Melatonin Levels in Patients with Minimal Cognitive Impairment and Alzheimer Disease
(Tubitak Scientific & Technical Research Council Turkey, 2015)Background/aim: F2 alpha-isoprostane is accepted as an oxidative stress indicator and melatonin shows neuroprotective effects by antioxidative and antiamyloidogenic influences. By measuring these in patients diagnosed with ... -
Development of Sensitive And Specific Analysis of Vildagliptin In Pharmaceutical Formulation By Gas Chromatography-Mass Spectrometry
(2015)A sensitive and selective gas chromatography-mass spectrometry (GC-MS) method was developed and fully validated for the determination of vildagliptin (VIL) in pharmaceutical formulation. Prior to GC-MS analysis, VIL was ... -
Induction Of Telomere Dysfunction Mediated By The Telomerase Substrate Precursor 6-Thio-2'-Deoxyguanosine
(Amer Assoc Cancer Research, 2015)The relationships between telomerase and telomeres represent attractive targets for new anticancer agents. Here, we report that the nucleoside analogue 6-thio-2'-deoxyguanosine (6-thio-dG) is recognized by telomerase and ... -
Rutin Ameliorates Methotrexate Induced Hepatic Injury in Rats
(Acta Cirurgica Brasileira, 2015)PURPOSE: To investigate the possible protective effect of rutin on methotrexate induced hepatotoxicity in rats. METHODS: Twenty-two rats were divided into three experimental groups; Control-saline, Mtx, Mtx+Rutin. Hepatic ... -
Specimen Rejection In Laboratory Medicine: Necessary For Patient Safety?
(2015)Introduction The emergency laboratory in Hacettepe University Hospitals receives specimens from emergency departments (EDs), inpatient services and intensive care units (ICUs). The samples are accepted according to the ...