Browsing Temel Eczacılık Bilimleri Bölümü by Title
Now showing items 48-67 of 189
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Development of Sensitive And Specific Analysis of Vildagliptin In Pharmaceutical Formulation By Gas Chromatography-Mass Spectrometry
(2015)A sensitive and selective gas chromatography-mass spectrometry (GC-MS) method was developed and fully validated for the determination of vildagliptin (VIL) in pharmaceutical formulation. Prior to GC-MS analysis, VIL was ... -
Development Of Titania Nanotube-Based Electrochemical Immunosensor And Determination Of Prostate Specific Antigen
(Japan Soc Analytical Chemistry, 2018)Early diagnosis of cancer is the most important factor that increases the success of treatment. Therefore, the development of new diagnostic tools is a necessity. In this study, a new electrode surface was developed via ... -
Diagnostic Implications Of Telomerase Activity In Pleural Effusions
(European Respiratory Soc Journals Ltd, 2003)The aim of the present study was to investigate the diagnostic efficacy of telomerase activity for discrimination of malignant and benign pleural effusions. Pleural effusions were collected from 109 consecutive patients ... -
Differential Requirement For The Atpase Domain Of The Cockayne Syndrome Group B Gene In The Processing Of Uv-Induced Dna Damage And 8-Oxoguanine Lesions In Human Cells
(Oxford Univ Press, 2002)Cockayne syndrome (CS) is a rare inherited human genetic disorder characterized by UV sensitivity, developmental abnormalities and premature aging. The cellular and molecular phenotypes of CS include increased sensitivity ... -
Discrimination Of The Effects Of Doxorubicin On Two Different Breast Cancer Cell Lines On Account Of Multidrug Resistance And Apoptosis
(Indian Pharmaceutical Assoc, 2017)Breast cancer is one of the most common cancer types and malfunctioning proteins in apoptotic pathways are known to be the main contributors of cancer development. In this study MCF-7 and MDA-MB-231 breast cancer cell lines ... -
Down Sendromunun Tanısına Yönelik Seçilmiş Metabolitlerin Gaz Kromatografisi Kütle Spektrometrisi ile Tayini
(Sağlık Bilimleri Enstitüsü, 2017-07-14)Down Syndrome is a common genetic disorder arising due to the condition that humans having an additional chromosome within 21st chromosome couple. Metabolomics is identification and quantification of small molecule metabolites ... -
Dünyada Yeni Aşı Üretiminde Uygulanan Toksikolojik Değerlendirmelerin Karşılaştırılması
(Sağlık Bilimleri Enstitüsü, 2023)Vaccines are complex biological medicinal products containing components such as antigens, adjuvants, and preservatives. They prevent diseasesby stimulating the immune system and providing active immunity. In the last ... -
Dynamic Phosphometabolomic Profiling of Human Tissues and Transgenic Models By O-18-Assisted P-31 Nmr and Mass Spectrometry
(Amer Physiological Soc, 2012)Next-generation screening of disease-related metabolomic phenotypes requires monitoring of both metabolite levels and turnover rates. Stable isotope O-18-assisted P-31 nuclear magnetic resonance (NMR) and mass spectrometry ... -
Dıscovery of New Indoleamıne 2,3-Dıoxygenase 1 (Ido1) Inhıbıtors Through Vırtual Screenıng
(Sağlık Bilimleri Enstitüsü, 2024-01-04)Cancer, a leading global cause of deaths, utilizes mechanisms and pathways to evade the immune system, one of which is the kynurenine (Kyn) pathway, responsible for degrading amino acid L-tryptophan (Trp). Overexpression ... -
Effect of Topically Applied Charged Particles on Healing of Colonic Anastomoses
(Amer Medical Assoc, 2002)Hypothesis: Various forms of electrical stimulation can improve wound healing in different tissues, but their application to gastrointestinal tract healing has not been investigated. We assumed that positively charged ... -
Effectiveness of Dimethylsulfoxide on The Survival and Volume Preservation of Autologous Fat Graft Tissue: A Preliminary Study
(Oxford Univ Press, 2016)Background: The survival of autologous fat graft tissue is dependent on various factors, such as vascularization and inflammation. Objective: This study aims to evaluate the possible beneficial effects of dimethylsulfoxide ... -
Effects Of Cadmium And Zinc Ions On Purified Lamb Kidney Cortex Glucose-6-Phosphate Dehydrogenase Activity
(Taylor & Francis Ltd, 2006)Glucose-6-phosphate dehydrogenase (G-6-PD) is the first enzyme in the pentose phosphate pathway. Cadmium is a toxic heavy metal that inhibits several enzymes. Zinc is an essential metal but overdoses of zinc have toxic ... -
Effects Of Rosiglitazone Treatment On The Pentose Phosphate Pathway And Glutathione-Dependent Enzymes In Liver And Kidney Of Rats Fed A High-Fat Diet
(Elsevier Science Inc, 2004)Background: Animals fed high-fat diets have been shown to develop hyperglycemia, insulin resistance, hyperlipidemia, and moderate obesity, which resemble the human metabolic syndrome. Obesity, the metabolic syndrome, and ... -
Effects Of Timolol Treatment On Pancreatic Antioxidant Enzymes In Streptozotocin-Induced Diabetic Rats: An Experimental And Computational Study
(2019)Background: The study aimed to investigate whether timolol-treatment has a beneficial effect on pentose phosphate pathway enzyme activities such as glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase ... -
Evaluation Of A Capillary Electrophoresis Method For Routine Determination Of Varenicline Tartrate In Quality-Control Laboratories
(Soc Chemists Technologists Madeconia, 2015)In this study, analyses were carried out on a fused-silica capillary (i.d. 50.0 mu m, total length 48.5 cm, and effective length 40.0 cm) in normal mode by applying a voltage of 20 kV. Sample injections were made in ... -
Evaluation Of Pharmaceutical Quality Of Conventional Dosage Forms Containing Paracetamol And Caffeine Available In The Turkish Drug Market
(Dissolution Technologies, Inc, 2016)The aim of this study was to evaluate the quality of conventional paracetamol- (PA) and caffeine- (CA) containing combined dosage forms in the Turkish drug market. For this purpose, weight variation, content uniformity, ... -
Evaluatıon of Developmental Toxıcıty of Ethephon Usıng Embryonıc Stem Cell Model
(Sağlık Bilimleri Enstitüsü, 2018-09-19)Mohammadi Nejad S. Evaluation of Developmental Toxicity of Ethephon Using Embryonic Stem Cell Model. Hacettepe University, Graduate School of Health Sciences, Pharmaceutical Toxicology Program, Doctor of Philosophy Thesis, ... -
Farmasötik Kimya
(Hacettepe Üniversitesi, 2004)Bu kitap, son yıllarda farmasötik kimya alanında gözlenen hızlı ve sürekli gelişmeleri aktaran Türkçe bir kaynak olarak hazırlanmıştır. Kitabın ilk üç baskısının akademik ve eczacılık çevrelerinde gördüğü ilgi nedeniyle ... -
Farmasötik Kimya 1
(Hacettepe Üniversitesi Yayınları, 2016)Bu kitap, son yıllarda farmasötik kimya alanında gözlenen hızlı ve sürekli gelişmeleri aktaran Türkçe bir kaynak olarak hazırlanmıştır. Kitabın ilk üç baskısının akademik ve eczacılık çevrelerinde gördüğü ilgi nedeniyle ...