Yayın tarihi için Temel Eczacılık Bilimleri Bölümü listeleme
Toplam kayıt 191, listelenen: 41-60
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The Use And Importance Of Liposomes In Positron Emission Tomography
(Taylor & Francis Ltd, 2012)Among different imaging modalities, Positron Emission Tomography (PET) gained importance in routine hospital practice depending on ability to diagnose diseases in early stages and tracing of therapy by obtaining metabolic ... -
18O-Assisted Dynamic Metabolomics for Individualized Diagnostics and Treatment of Human Diseases
(2012)Technological innovations and translation of basic discoveries to clinical practice drive advances in medicine. Today's innovative technologies enable comprehensive screening of the genome, transcriptome, proteome, and ... -
Farmasötik Preparatlardan ve Gıdalardan Tobramisin Tayini İçin Moleküler Baskılanmış Nanosensörlerin Geliştirilmesi
(Sağlık Bilimleri Enstitüsü, 2013)In this thesis study, the molecularly imprinted glassy carbon and quartz crystal microbalance (QCM) nanosensors were developed for the determination of tobramycin. For QCM nanosensor, firstly the modification of gold surface ... -
Karaciğer ve Meme Kanseri Hücreleri ile Embriyonik Böbrek Hücrelerinde Doksorubisinin Apoptotik Genlerin ve Mdr-1 Geninin Ekspresyon Düzeylerine Etkisi
(Sağlık Bilimleri Enstitüsü, 2013)In this study, in order to investigate roles of certain genes and expression levels of these genes in apoptosis, MCF-7 (breast), HEPG2 (liver) cancer cells and HEK293 embryonic kidney cells were treated with increasing ... -
Development and Validation of an Ultra-Performance Liquid Chromatographic-Tandem Mass Spectrometry (Uplc-Ms/Ms) Method for Determination of Betamethasone or Dexamethasone in Pharmaceutical Preparations
(Sağlık Bilimleri Enstitüsü, 2013)Development and Validation of an Ultra-Performance Liquid Chromatographic-Tandem Mass Spectrometry (UPLC-MS/MS) Method for Determination of Betamethasone or Dexamethasone in Pharmaceutical Preparations, Hacettepe University, ... -
Metastatik Meme Kanseri Hücrelerinde Mtor Üzerine Etkili Bazı Mekanizmaların Araştırılması
(Sağlık Bilimleri Enstitüsü, 2013)Signal trunsduction pathways play crucial roles in breast cancer pathogenesis. mTOR, which plays a central role in cell proliferation and interacts with several cell components, is selected as a target in MDA-MB- 231 ... -
Ht29 Ve K562 Kanser Hücrelerinde Protein ve Metabolitlerin Analizi Için Çeşitli Analitik Yöntemlerin Geliştirilmesi
(Sağlık Bilimleri Enstitüsü, 2013)Cancer is one of the most dangerous fatal diseases threating the human being both economically and socially. Therefore, the studies are performed on molecular level to understand cancer on molecular level and prevent the ... -
Leflunomid In Farmasötik Preparatlardan Analizi Için Kapiler Elektroforez Yöntemi Geliştirilmesi ve Validasyonu
(Sağlık Bilimleri Enstitüsü, 2013)In this study, a new micellar electrokinetic capillary chromatography (MEKC) method was developed to analysis of Leflunomide in pharmaceutical preparations. Best results in the MEKC method were obtained by the use of pH ... -
Lökosit Miyeloperoksidaz Enziminin Saflaştırılması, Kinetik Özellikleri ile Reaktif Türlerin Oluşumundaki Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2013)Myeloperoxidase (MPO) has been purified from human leucocytes obtained by leukapheresis, and kinetic properties were determined, nitrite oxidation and tyrosine nitration catalyzed by the purified enzyme have been studied. ... -
Nnav1.5 Sodyum Kanalı ve Noç-4 Reseptör Sinyalinin Baskılanmasının İnsan Meme Kanseri Hücrelerinde Çoğalma ve Metastatik Potansiye Üzerine Etkisinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2013)The incidence of breast cancer is rapidly increasing and it is one of the major causes of death. The molecular changes leading to malignant transformation and metastasis of mammary cells is studied intensively. The expression ... -
In Cellulo Examination Of A Beta-Alpha Hybrid Construct Of Beta-Hexosaminidase A Subunits, Reported To Interact With The Gm2 Activator Protein And Hydrolyze Gm2 Ganglioside
(2013)The hydrolysis in lysosomes of GM2 ganglioside to GM3 ganglioside requires the correct synthesis, intracellular assembly and transport of three separate gene products; i.e., the alpha and beta subunits of heterodimeric ... -
Activation and Regioselectivity of Five-Membered Cyclic Thionocarbamates to Nucleophilic Attack
(Royal Soc Chemistry, 2013)The cyclic thionocarbamate of alaninol undergoes nucleophilic attack by sulfur nucleophiles at 5-C to give 1-thiopropyl-2-amine derivatives when derivatised on nitrogen with a Boc group. Iodide under microwave conditions ... -
Optimization Of A Gas Chromatography-Mass Spectrometry Method Using Chemometric Techniques For The Determination Of Ezetimibe In Human Plasma
(Scientific Technical Research Council Turkey-Tubitak, 2013)A new, rapid, and sensitive gas chromatography-mass spectrometry (GC-MS) method was developed for the determination of ezetimibe (EZE) in human plasma. EZE was derivatized prior to GC-MS analysis. Various derivatization ... -
Monitoring The Perturbation Of Soil And Groundwater Microbial Communities Due To Pig Production Activities
(Amer Soc Microbiology, 2013)This study aimed to determine if biotic contaminants originating from pig production farms are disseminated into soil and groundwater microbial communities. A spatial and temporal sampling of soil and groundwater in proximity ... -
Polyproline Tetramer Organizing Peptides in Fetal Bovine Serum Acetylcholinesterase
(Elsevier Science Bv, 2013)Acetylcholinesterase (AChE) in the serum of fetal cow is a tetramer. The related enzyme, butyrylcholinesterase (BChE), in the sera of humans and horse requires polyproline peptides for assembly into tetramers. Our goal was ... -
Rp-Hplc Method Development and Validation for Estimation of Rivaroxaban in Pharmaceutical Dosage Forms
(Univ Sao Paulo, Conjunto Quimicas, 2013)Rivaroxaban, an anti-clotting medication, acts at a crucial point in the blood-clotting process and stops the formation of blood clots. In this study, RP-HPLC method was developed for the determination of rivaroxaban in ... -
İnsan Serum Bütirilkolinesterazı ve Eritrosit Asetilkolinesterazının Statin Türevleri ile Etkileşiminin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2014)To investigate effects of statins on cholinesterases, Butyrylcholinesterase (BChE; E.C.3.1.1.8 ) was purified from human plasma through acid dialysis, DEAE-Tris Acryl M ion exchange and Procainamide-Sepharose 4B chromatography ... -
Fetal Sığır Serum Asetilkolinesterazının Tetramerik Yapısını Organize Eden Poliprolin Peptidlerin Kütle Spektrometre ile Analizi
(Sağlık Bilimleri Enstitüsü, 2014)Acetylcholinesterase (AChE) in the serum of fetal bovine is a tetrameric enzyme. The related enzyme, butyrylcholinesterase (BChE), in the sera of humans and horse requires polyproline peptides for assembly into tetramers. ... -
Changes in the Vascular Tissue Protein Profile of the Diabetic Rats and the Protective Role of the Beta Blockers
(Sağlık Bilimleri Enstitüsü, 2014)Cardiovascular complication is the main cause of mortality in diabetes mellitus. Beta blockers are groups of drugs that used in the treatment of heart disease in diabetes mellitus. The object of this study is to investigate ...