Bölüm "Analitik Kimya" Temel Eczacılık Bilimleri Bölümü için listeleme
Toplam kayıt 48, listelenen: 21-40
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Dynamic Phosphometabolomic Profiling of Human Tissues and Transgenic Models By O-18-Assisted P-31 Nmr and Mass Spectrometry
(Amer Physiological Soc, 2012)Next-generation screening of disease-related metabolomic phenotypes requires monitoring of both metabolite levels and turnover rates. Stable isotope O-18-assisted P-31 nuclear magnetic resonance (NMR) and mass spectrometry ... -
Evaluation Of A Capillary Electrophoresis Method For Routine Determination Of Varenicline Tartrate In Quality-Control Laboratories
(Soc Chemists Technologists Madeconia, 2015)In this study, analyses were carried out on a fused-silica capillary (i.d. 50.0 mu m, total length 48.5 cm, and effective length 40.0 cm) in normal mode by applying a voltage of 20 kV. Sample injections were made in ... -
Evaluation Of Pharmaceutical Quality Of Conventional Dosage Forms Containing Paracetamol And Caffeine Available In The Turkish Drug Market
(Dissolution Technologies, Inc, 2016)The aim of this study was to evaluate the quality of conventional paracetamol- (PA) and caffeine- (CA) containing combined dosage forms in the Turkish drug market. For this purpose, weight variation, content uniformity, ... -
Farmasötik Ürünlerde Tüketilebilirlik Çalışmalarına Analitik Yaklaşımlar
(Sağlık Bilimleri Enstitüsü, 2023-12-21)Ignoring the effects of extractable substances not only creates great difficulties for drug manufacturers and regulations, but also changes the safety of the drug due to the dangers that impurities may cause. The suitability ... -
Glioblastoma Multiforme, Menenjiyom (Birincil) ve Metastaz (İkincil) Beyin Tümörlerine Ait Fenotiplerin Belirlenmesinde Kullanılacak Bütünleşik Omiks Analizler İçin Analitik Yöntem Geliştirilmesi ve Uygulanması
(Sağlık Bilimleri Enstitüsü, 2022)A thorough examination of intermediate molecular levels such as protein, metabolite, and lipid is required to establish direct causal and functional links between genotype and phenotype. Comprehensive metabolomics and ... -
H2 Reseptör Antagonistlerinin Yeşil Hplc Ayırımı İçin Kemometrik Optimizasyon Yaklaşımı ve Famotidin İçeren Farmasötik Preparatlara Uygulanması
(Sağlık Bilimleri Enstitüsü, 2022)H2 receptor antagonists are often preferred in gastroesophageal reflux disease or in the treatment of gastric acidity disorders. In this thesis, an HPLC method for simultaneous analysis of H2 receptor antagonists, famotidine, ... -
Hplc Method Development For The Simultaneous Analysis Of Amlodipine And Valsartan In Combined Dosage Forms And In Vitro Dissolution Studies
(Univ Sao Paulo, Conjunto Quimicas, 2010)A simple, rapid and reproducible HPLC method was developed for the simultaneous determination of amlodipine and valsartan in their combined dosage forms, and for drug dissolution studies. A C 18 column (ODS 2, 10 mu m, 200 ... -
Kardiyopulmoner Baypas Sonrası Gelişen Akut Böbrek Yetmezliğinin Erken Tanısı İçin Omiks Yaklaşımlar ve Elektroanalitik Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2022-09-09)Patients exposed to cardiopulmonary bypass may develop acute renal failure (ARF) as a result of blood coming into contact with the heart-lung machine circuits. The serum creatinine level is checked for the diagnosis of ... -
Meme Kanserinde Hedeflenmiş Metabolitlerin LC-MS/MS Yöntemi ile Tayinleri
(Sağlık Bilimleri Enstitüsü, 2019)The best preventive method for breast cancer, which accounts for 18% of the most common cancer-related deaths among women, is the early diagnosis. Metabolomic analyzes have an important role in early diagnosis and tracking ... -
Metabolomik Ve Fluksomik Çalışmalar ile Kolon Kanserinde Kemoterapötiklere Karşı Direncin in Vitro Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2019-06-25)Özen G., In Vitro Analysis of Resistance to Chemotherapeutics in Colon Cancer by Metabolomic and Fluxomic Studies, Hacettepe University Graduate of Health Sciences, Analytical Chemistry Program, Ph.D. Thesis, Ankara, 2019. ... -
Modulation Of Mitochondrial Complex I Activity Averts Cognitive Decline In Multiple Animal Models Of Familial Alzheimer'S Disease
(2015)Development of therapeutic strategies to prevent Alzheimer's disease (AD) is of great importance. We show that mild inhibition of mitochondrial complex I with small molecule CP2 reduces levels of amyloid beta and phospho-Tau ... -
Momordıca Charantıa L. Ekstrelerinin İçeriğinin ve Melanoma Kanser Hücreleri Üzerine Etkisinin Metabolomik Çalışmalarla İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2023-08)In this thesis study, Momordica charantia L. (bitter gourd) used in wound healing was investigated at the metabolome level with metabolomic studies based on Liquid Chromatography/Quadrapol Time-of-Flight Mass Spectrometry ... -
Non-Enzymatic Electrochemical Sensing Of Malathion Pesticide In Tomato And Apple Samples Based On Gold Nanoparticles-Chitosan-Ionic Liquid Hybrid Nanocomposite
(2018)Malathion (MLT) is an organophosphorous type pesticide and having seriously high toxicity and electrochemical platforms for rapid, simple, inexpensive and sensitive determination of pesticides is still a special concern. ... -
Optimization Of A Gas Chromatography-Mass Spectrometry Method Using Chemometric Techniques For The Determination Of Ezetimibe In Human Plasma
(Scientific Technical Research Council Turkey-Tubitak, 2013)A new, rapid, and sensitive gas chromatography-mass spectrometry (GC-MS) method was developed for the determination of ezetimibe (EZE) in human plasma. EZE was derivatized prior to GC-MS analysis. Various derivatization ... -
P-31 Nmr Correlation Maps Of O-18/O-16 Chemical Shift Isotopic Effects For Phosphometabolite Labeling Studies
(Springer, 2011)Intramolecular correlations among the O-18-labels of metabolic oligophosphates, mapped by J-decoupled P-31 NMR 2D chemical shift correlation spectroscopy, impart stringent constraints to the O-18-isotope distributions over ... -
Parasetamolün Parenteral Çözeltide Stabilite Göstergeli Miktar Tayini İçin Yüksek Performanslı Sıvı Kromatografisi Yöntemi Geliştirilmesi ve Validasyonu
(Sağlık Bilimleri Enstitüsü, 2022-09-20)The analytical validation of the parenteral solution in the semi-permeable primary bag and the non-permeable primary vial packaging containing the active ingredient Paracetamol was completed by developing a stability ... -
Proguanil Metabolism in Relation To S-Mephenytoin Oxidation in A Turkish Population
(Blackwell Science Ltd, 1996)The oxidation of proguanil was studied in 89 unrelated healthy Turkish volunteers after administration of proguanil (single dose, 200 mg, orally). Based on the distribution of the ratio of proguanil to cycloguanil excreted ... -
Rp-Hplc Method Development and Validation for Estimation of Rivaroxaban in Pharmaceutical Dosage Forms
(Univ Sao Paulo, Conjunto Quimicas, 2013)Rivaroxaban, an anti-clotting medication, acts at a crucial point in the blood-clotting process and stops the formation of blood clots. In this study, RP-HPLC method was developed for the determination of rivaroxaban in ...