Browsing Temel Eczacılık Bilimleri Bölümü by Issue Date
Now showing items 21-40 of 189
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Increased Levels Of Nitric Oxide, Cortisol And Adrenomedullin In Patients With Chronic Schizophrenia
(Karger, 2007)Objective: To investigate the levels of serum cortisol, dehydroepiandrosterone sulfate (DHEA-S), nitric oxide (NO) and adrenomedullin (AM) in schizophrenic patients. Subjects and Methods: Sixty-six male patients with chronic ... -
Development And In Vitro Evaluation Of Pantoprazole-Loaded Microspheres
(Informa Healthcare, 2008)Pantoprazole is a proton pump inhibitor prodrug used in the treatment of gastric ulcers and gastroesophageal disease. Pantoprazole must be absorbed in the gastrointestinal tract and because it is unstable under acidic ... -
Simultaneous Spectrophotometric Determination Of Ezetimibe And Simvastatin In Pharmaceutical Preparations Using Chemometric Techniques
(Soc Brasileira Quimica, 2008)Two spectrophotometric methods are described for the simultaneous determination of ezetimibe (EZE) and simvastatin (SIM) in pharmaceutical preparations. The obtained data was evaluated by using two different chemometric ... -
In Vivo And In Vitro Effects Of A Hif-1 Alpha Inhibitor, Rx-0047
(Wiley, 2008)HIF-1 alpha plays a major role in activating gene transcription and is important for maintaining homeostasis under hypoxic conditions. Since tumors are often in a hypoxic state, HIF-1 alpha is a potential target for the ... -
Örneklerle Organik Kimya Nomenklatürü
(Hacettepe Üniversitesi, 2008)Bilimsel yaşamımız ve eğitimimizin en önemli sorunlardan birisi Türkçe kitap eksikliğidir. Nomenklatür konusundaki bu eksikliği gidermek amacı ile 1995 yılında "Organik Kimya Nomenklatürü" isimli kitabımızı yayınlamıştık. ... -
Lactoferrin In Gingival Crevicular Fluid And Peripheral Blood During Experimental Gingivitis
(2009)Objectives Lactoferrin (LF) is an iron binding protein and stored in the specific granules of granulocytes. It is released by degranulation following granulocyte activation. A positive correlation was previously reported ... -
Fetal Allogeneic Umbilical Cord Cell Transplantation Improves Motor Function In Spinal Cord-Injured Rats
(Turkish Neurosurgical Soc, 2010)AIM: The objective of this study was to investigate whether the transplantation of fetal umbilical cord tissue cells as a source of stem cells into the acutely injured spinal cord would produce some regenerations and/or ... -
Hplc Method Development For The Simultaneous Analysis Of Amlodipine And Valsartan In Combined Dosage Forms And In Vitro Dissolution Studies
(Univ Sao Paulo, Conjunto Quimicas, 2010)A simple, rapid and reproducible HPLC method was developed for the simultaneous determination of amlodipine and valsartan in their combined dosage forms, and for drug dissolution studies. A C 18 column (ODS 2, 10 mu m, 200 ... -
Methamidophos, Dichlorvos, O-Methoate And Diazinon Pesticides Used In Turkey Make A Covalent Bond With Butyrylcholinesterase Detected By Mass Spectrometry
(Wiley, 2010)Organophosphorus pesticides used most commonly in Turkey include methamidophos, dichlorvos, O-methoate and diazinon. These toxic chemicals or their metabolites make a covalent bond with the active site serine of ... -
Investigating the Structural Influence of Surface Mutations on Acetylcholinesterase Inhibition by Organophosphorus Compounds and Oxime Reactivation
(Elsevier Ireland Ltd, 2010)Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Binary mixtures of mammalian AChE and oximes of varying structure have ... -
Stereological Analysis Of Sciatic Nerve In Chickens Following Neonatal Pinealectomy: An Experimental Study
(2010)Background Although the injury to the peripheral nervous system is a common clinical problem, understanding of the role of melatonin in nerve degeneration and regeneration is incomplete. Methods The current study investigated ... -
Simultaneous Determination of Ezetimibe and Simvastatin in Pharmaceutical Preparations by MEKC
(Preston Publications Inc, 2010) -
Nonsteroidal Antiinflarmatur İlaçların Toksikolojisi
(Hacettepe Üniversitesi, 2010)Zehirlenmeler yetişkin ve çocuk acil servisleri başta olmak üzere sık karşılaşılan klinik durumlardan biridir. Zehirlenme tedavisinde zamanında ve uygun müdahalenin önemi büyüktür. Zehirlenmeler içerisinde ilaca bağlı ... -
P-31 Nmr Correlation Maps Of O-18/O-16 Chemical Shift Isotopic Effects For Phosphometabolite Labeling Studies
(Springer, 2011)Intramolecular correlations among the O-18-labels of metabolic oligophosphates, mapped by J-decoupled P-31 NMR 2D chemical shift correlation spectroscopy, impart stringent constraints to the O-18-isotope distributions over ... -
In Vitro Effects Of Rosmarinic Acid On Glutathione Reductase And Glucose 6-Phosphate Dehydrogenase
(Taylor & Francis Ltd, 2011)Context: Glutathione reductase (GR, NADPH:oxidized glutathione oxidoreductase, E. C 1.6.4.2) is a flavoprotein that catalyzes the NADPH-dependent reduction of oxidized glutathione (GSSG). GR is a crucial enzyme in the ... -
Raloksifen'in Biyolojik Materyalden ve Farmasötik Preparattan Analizi İçin Gaz Kromatografisi-Kütle Spektrometrisi Yönteminin Geliştirilmesi ve Valide Edilmesi
(Sağlık Bilimleri Enstitüsü, 2012)Raloxifene is selective estrogen modulator (SERM) drug which is used in the treatment of postmenopausal osteoporosis in women and used for doping in men. A new gas chromatography-mass spectrometry (GC-MS) method was developed ... -
Özgün Heterosiklik Bileşiklerin Glutatyon Transferaz P1-1 İnhibitörleri Olarak Araştırılması ve İnsan Meme Kanser Hücreleri Üzerine Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2012)The aim of this project is to design inhibitors for GST P1-1 and test their effectiveness on breast cancer cells. For this purpose benzoxazole, benzimidazole, benzothiazole derivative compounds were synthesized. Recombinant ... -
Dynamic Phosphometabolomic Profiling of Human Tissues and Transgenic Models By O-18-Assisted P-31 Nmr and Mass Spectrometry
(Amer Physiological Soc, 2012)Next-generation screening of disease-related metabolomic phenotypes requires monitoring of both metabolite levels and turnover rates. Stable isotope O-18-assisted P-31 nuclear magnetic resonance (NMR) and mass spectrometry ... -
Antioxidant and Cytotoxic Effects of Moltkia Aurea Boiss
(Acg Publications, 2012)The water extract of M. aurea exhibited strong scavenging effect on 2,2-diphenyl-1-picrylhydrazil (DPPH), nitric oxide (NO) and superoxide (SO) radicals. The free radical scavenging effect of the extract was found comparable ... -
The Proline-Rich Tetramerization Peptides In Equine Serum Butyrylcholinesterase
(Wiley-Blackwell, 2012)Soluble, tetrameric, plasma butyrylcholinesterase from horse has previously been shown to include a non-covalently attached polyproline peptide in its structure. The polyproline peptide matched the polyproline-rich region ...