Browsing Eczacılık Teknolojisi Bölümü by Department "Farmasötik Teknoloji"
Now showing items 21-40 of 55
-
Development of Polycationic Amphiphilic Cyclodextrin Nanoparticles for Anticancer Drug Delivery
(2017)Background: Paclitaxel is a potent anticancer drug that is effective against a wide spectrum of cancers. To overcome its bioavailability problems arising from very poor aqueous solubility and tendency to recrystallize upon ... -
Diyabetik Yara Tedavisinde Kullanılmak Üzere Nanopartiküler Statin ve Kök Hücre İçeren Doku İskelelerinin Formülasyonu ve İn Vitro/İn Vivo Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2017)Simvastatin has been shown to support wound healing and stem cell treatment efficacy independent of cholesterol-lowering mechanism in recent studies. Under the light of these facts, in order to provide a new treatment approach ... -
Doksorubisin ve elakridar içeren PLGA/silika hibrit nanopartiküllerin formülasyonu ve meme kanserindeki etkinliğinin değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2019)Although doxorubicin is efficient alone in cancer treatment, its being a substrate of P-glycoprotein (P-gp) limits its effectiveness. Various approaches have been developed to overcome the growing resistance to these drugs. ... -
Effect of Locally Applied Transforming Growth Factor Beta3 on Wound Healing and Stenosis Development in Tracheal Surgery
(Daedalus Enterprises Inc, 2014)BACKGROUND: Tracheal stenosis constitutes one of the most frequently seen problems in thoracic surgery. Although many treatment modalities to prevent fibroblast proliferation, angiogenesis, or inflammation that causes ... -
Effect Of Particle Size And Surfactant On The Solubility, Permeability And Dissolution Characteristics Of Deferasirox
(2019)Deferasirox is an oral iron chelator used for the treatment of chronic iron overload in blood transfusions. Deferasirox is a BCS Class II drug with low solubility and high permeability. In the formulation development stage ... -
Effect of Topically Applied Sildenafil Citrate on Wound Healing: Experimental Study
(Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, 2014)Wound healing is a complex process that necessitates organization of different cell types and several signalling molecules. The aim of this study is to evaluate the effect of different concentrations of sildenafil citrate, ... -
Effects Of Transforming Growth Factor-Beta-1 Neutralizing Antibody And Transforming Growth Factor-Beta-3 On The Development Of Tracheal Stenosis
(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2017)Background: This study aims to evaluate the effects of transforming growth factor-beta 3 and neutralizing antibody of transforming growth factor-beta 1 containing polymeric polycaprolactone film formulations on prevention ... -
Estimation Of Aqueous Distributional Spaces In The Dual Perfused Rat Liver
(Cambridge Univ Press, 2000)1. The aim of this study was to estimate the aqueous distributional spaces of the liver as a function of the route of input: portal vein (PV) versus hepatic artery (HA). 2. Studies were performed in the in situ single (PV) ... -
Farklı Şekilli Nanopartiküllerin Geliştirilmesi, İmmünoterapötik ve Kemoterapötik Madde Yüklü Optimum Şekilli Nanopartiküllerin Küçük Hücreli Dışı Akciğer Kanseri Üzerine Antikanser Etkinliğinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2024-02)Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancers. Cancer immunotherapy, offers new opportunities for the treatment of lethal lung cancer, immune checkpoint inhibitors used in the treatment of NSCLC ... -
Few Drugs Display Flip-Flop Pharmacokinetics And These Are Primarily Associated With Classes 3 And 4 Of The Bddcs
(Wiley, 2015)This study was conducted to determine the number of drugs exhibiting flip-flop pharmacokinetics following oral (p.o.) dosing from immediate-release dosage forms and if they exhibit a common characteristic that may be ... -
Hedeflendirilmiş Antikanser İlaç Yüklü Polimerik Nanotaşıyıcıların Formülasyonları ve Karakterizasyonları
(Sağlık Bilimleri Enstitüsü, 2019)The distribution of the drugs used in cancer chemotherapy without distinction between the diseased area and the healthy area causes damage to healthy tissue. By using targeted drug delivery systems it is intended to ... -
Hipertansiyon Tedavisinde Etkili Çözünürlük Sorunu Olan Bir Etkin Madde Üzerinde Önformülasyon Çalışmaları
(Sağlık Bilimleri Enstitüsü, 2022-09-19)This thesis aims to improve the poor solubility of M3, a molecule that can block both L-type and T-type calcium channels, with nanocrystal technology (NKT), and to develop orally disintegrating film (ADF) formulations ... -
İmmünokemoterapötik Nanoplekslerin Kolon Kanseri Tedavisinde Etkinlik ve Güvenliliğinin İn Vitro-İn Vivo Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2022-10-19)Chemotherapy is the most commonly used method after surgery in the treatment of colon cancer. However, cancer cells escape the recognition mechanism of immune system cells in to survive, developing resistance to chemotherapeutics ... -
İrinotekan ve stat3 inhibitörü yüklü plgapeg nanopartiküllerinin küçük hücreli akciğer kanserine aktif hedeflendirilmesi ve in vivo-in vitro değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2023-02)Small cell lung cancer accounts for 13-15% of all lung cancer cases. It spreads rapidly and has significant metastasis potential thus it is difficult to cure. In the concept of this thesis, polymeric nanoparticles actively ... -
Karaciğerdeki İlaç Dispozisyonu Üzerine Rifampisinin Etkisinin İncelenmesi ve Farmakokinetik Modelleme
(Sağlık Bilimleri Enstitüsü, 2020)Transporter-mediated pharmacokinetics is one of the determinants in hepatic drug disposition and drug-drug interactions. Among several influx (uptake) transporters expressed in the membranes of hepatocytes, hepatic organic ... -
Kemik Metastazlarının Tedavisinde Etkili Nanopartikül Formülasyonlarının Geliştirilmesi, Optimizasyonu ve In Vitro Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2017)Kozlu, S., Formulation Development, Optimisation and In Vitro Evaluation of Nanoparticles Effective to Bone Methastasis, Hacettepe University Institute of Health Sciences Department of Pharmaceutical Technology Doctor of ... -
Keratokonus Tedavisinde Riboflavin’in Girişimsel Olmayan (“Epi-On”) Teknik ile Korneaya Taşınması İçin Oküler İlaç Taşıyıcı Platformların Tasarlanması ve İn Vitro-İn Vivo Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2020-08-13)Aytekin E. Design and In vitro - In vivo Evaluation of Ocular Drug Delivery Platforms for the Delivery of Riboflavin by Noninvasive (“Epi-On”) Technique in the Treatment of Keratoconus, Hacettepe University Graduate School ... -
Kolorektal Kanserlerin Lokal Tedavisinde Oral Uygulanabilen Nanopartiküler İlaç Taşıyıcı Sistem Geliştirilmesi ve İn Vitro/İn Vivo Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2020)Anticancer drugs need to be administered via the parenteral route because of limitations arising from their physicochemical properties. Non-specific biodistribution and difficulty in parenteral administration adversely ... -
Lantanyum Karbonat Formülasyonlarının Hazırlanması, In-Vıtro Değerlendirilmesi ve Biyoaktivite Çalışmaları
(Sağlık Bilimleri Enstitüsü, 2018)Pınarbaşlı, O., Preparation of Lanthanum Carbonate Formulations, In-vitro Evaluation and Bioactivity Studies. Hacettepe University, Institute of Health Sciences, Doctor of Philosophy Thesis, Biopharmaceutics and Pharmacokinetics ...