Zayıflama Diyeti Alan Metabolik Sendrom Hastalarında Biyokimyasal ve Antropometrik Değişkenler ile CD36 Düzeyi Arasındaki İlişki

Abstract

This study was planned to evaluate the effect of weight loss diet on biochemical and anthropometric variables and CD36 level on 80 patients with newly diagnosed metabolic syndrome (MetS) who started weight loss diet. The study was completed with a total of 65 individuals, 49 females and 16 males, with a mean age of 44.27±10.80 years with newly diagnosed MetS who applied to the Ordu University Training and Research Hospital Internal Medicine Outpatient Clinic. At the beginning of the study, the individuals participating in the study were given a medical nutrition therapy (MNT), which was suitable for their energy and nutritional requirements and lifestyle, and that they would lose at least 5% weight in 8 weeks, and the patients were followed up at regular intervals. Before the MNT, information about the general characteristics and eating habits of the individuals was taken face to face by the researcher; before the MNT and at the end of the 8th week, 24-hour retrospective food consumption and anthropometric measurements of the individuals were made by the researcher, biochemical measurements were recorded from the patient file, blood pressure measurements were taken by the physician, and a tube of fasting blood was taken to determine CD36 levels and stored at -80°C until analysis. At the end of the study, 32 people with MetS strictly applied MNT; women (n=23) lost -8.85 ± 2.45, men (n=9) -12.34 ± 3.86 kg and lost MNT. Decreases were observed in fasting blood glucose, LDL, VLDL, total cholesterol, triglyceride, CRP, insulin, Homa-IR, AST, ALT levels and systolic blood pressure compared to those who did not comply with medical nutrition therapy (MNT) (p<0.05). There was a weak negative correlation between CD36 levels and the percentage of energy from dietary fat (r=-0.358, p<0.05). There was a weak positive correlation between CD36 levels and fasting blood glucose (r=0.390, p<0.05); a moderate positive correlation between CD36 and ALT (r=0.402, p<0.05) and CRP (r=-0.455, p<0.05) (p<0.05). There was a negative correlation between CD36 levels and body weight, BMI, hip circumference, waist/hip ratio, body fat mass and body fat percentage; a positive correlation was found between CD36 levels and lean tissue mass, lean tissue percentage (p<0.05). On the other hand, there was no difference between the groups in terms of CD36 levels at the end of the study (p>0.05). As a result; it can be said that CD36 is an important parameter for MetS, but weight loss does not affect CD36 levels.