Kord Kanında Bisfenol A ve Vitamin D Düzeyleri Arasındaki İlişki

Abstract

Bisphenol A (BPA) is a very common endocrine disruptor in daily life, lately some studies showed one of its negative effects on human health is on vitamin D metabolism. BPA can cross the placental barrier and it has been detected in maternal and fetal serum, human placenta, cord blood and amniotic fluid . The presence of BPA in the cord blood is an indication that the baby is affected in the prenatal period. In our country, BPA is commonly detected in cord blood in some studies. In recent years, vitamin D deficiency is frequently reported in newborn babies. The negative relationship between BPA and vitD has been shown in in the adult studies. Therefore, in our study, we aimed to investigate the relationship between BPA exposure and vitD levels in newborn babies. 98 mother-infant couples who applied to Ankara Etlik Zübeyde Hanım Gynecology Training and Research Hospital Gynecology and Obstetrics Service and gave consent to the study were included in the study. Questionnaire forms were given to the mothers. Prenatal possible BPA exposure were questioned; and the baby's birth weight, birth length, gestational week, mother's age, number of pregnancies, pre-postnatal weight and height were recorded from their files. Mean gestational week was 39,1 ± 1 weeks, mean birth weight was 3292 g ± 434 grams. In the cord blood of the cases, the median 25(OH)D level was 14.87 ng/mL (3.94-69.09 ng/mL), IQR: 11,25; median 1.25(OH)2D level was 53.3 pg/dL, IQR: 56.17. Vitamin D deficiency (25(OH)D <20 ng/mL) in 76,5% and severe vitD deficiency (25(OH)D ≤5 ng/mL ) in 8% of the cases. Using a vitamin D/containing preparation during pregnancy did not have an effect on vitamin D deficiency and 1,25(OH)2D tertile (p=0.573, p=0.859), but it has a statistically significant effect on the conversion rate of 25(OH)D to 1,25(OH)2D (p=0.002). If gravida is 3 or more (p=0.015), if the type of birth is CS (p=0.035), if maternal age is 30 and over (p=0.012) and if the mother has anemia at birth (p=0.002) it was found statistically significant to be below the 1,25(OH)2D 3rd tertile. BPA was detectable in 72.4% of cord blood; median BPA level was 1.57 ng/mL (0.06-17.6 ng/mL), IQR: 4.05. There was no significant relationship between cord blood BPA levels and the mother's possible BPA exposure history during pregnancy. If the gestational week increases (p=0.006), the pregnancy is the first or second pregnancy (p=0.008) and the weight gain is less/more than expected in pregnancy according to BMI (p=0.016), detection of BPA above 1 ng/mL was found to be statistically significant. No correlation was found between BPA tertile and vitamin D deficiency and 1,25(OH)2D tertile. (p=0.824; p=0.871) Also, no correlation was found between BPA levels above 1 ng/mL and vitamin D deficiency or 1,25(OH)2D tertile. (p=0.836; p=0.136). The relationship between the cord blood BPA and vitD levels could not be demonstrated in this very limited number of cases. More studies on larger number of mother infant pairs are needed to show if maternal BPA exposure have decreasing effect on newborn VitD levels.