Başlık için Temel Eczacılık Bilimleri Bölümü Tez Koleksiyonu listeleme
Toplam kayıt 60, listelenen: 9-28
-
Betametazon sodyum fosfat ve betametazon dipropiyonat’ın bozunma ürünlerinin varlığında yüksek basınçlı sıvı kromatografisi ile aynı anda analizleri
(Sağlık Bilimleri Enstitüsü, 2023-01)Betamethasone Sodium Phosphate and Betamethasone Dipropionate active ingredients and preservatives were analyzed in the presence of degradation products by HPLC method. -
Biyobozunur Poliüretan Bazlı Sert Doku Malzemelerinin Geliştirilmesi
(Sağlık Bilimleri Enstitüsü, 2018)It is important to develop hard tissue support products and innovative biomaterials for bone injuries. In this thesis, it is aimed to develop biodegradable polyurethane based bone regenerative films as hard tissue ... -
Caco2 Kolon Kanseri Hücrelerinde Ultra Performanslı Sıvı Kromatografisi-kütle Spektroskopisi Bazlı Proteomik Çalışmalar
(Sağlık Bilimleri Enstitüsü, 2017-01)Cancer is the one of the most difficult disease to detect and treat. By omic technologies it has been analyzed at molecular level about cancer. Among the omic technologies Proteomic, has been studied intensively worldwide, ... -
Changes in the Vascular Tissue Protein Profile of the Diabetic Rats and the Protective Role of the Beta Blockers
(Sağlık Bilimleri Enstitüsü, 2014)Cardiovascular complication is the main cause of mortality in diabetes mellitus. Beta blockers are groups of drugs that used in the treatment of heart disease in diabetes mellitus. The object of this study is to investigate ... -
Development and Validation of an Ultra-Performance Liquid Chromatographic-Tandem Mass Spectrometry (Uplc-Ms/Ms) Method for Determination of Betamethasone or Dexamethasone in Pharmaceutical Preparations
(Sağlık Bilimleri Enstitüsü, 2013)Development and Validation of an Ultra-Performance Liquid Chromatographic-Tandem Mass Spectrometry (UPLC-MS/MS) Method for Determination of Betamethasone or Dexamethasone in Pharmaceutical Preparations, Hacettepe University, ... -
Down Sendromunun Tanısına Yönelik Seçilmiş Metabolitlerin Gaz Kromatografisi Kütle Spektrometrisi ile Tayini
(Sağlık Bilimleri Enstitüsü, 2017-07-14)Down Syndrome is a common genetic disorder arising due to the condition that humans having an additional chromosome within 21st chromosome couple. Metabolomics is identification and quantification of small molecule metabolites ... -
Dünyada Yeni Aşı Üretiminde Uygulanan Toksikolojik Değerlendirmelerin Karşılaştırılması
(Sağlık Bilimleri Enstitüsü, 2023)Vaccines are complex biological medicinal products containing components such as antigens, adjuvants, and preservatives. They prevent diseasesby stimulating the immune system and providing active immunity. In the last ... -
Dıscovery of New Indoleamıne 2,3-Dıoxygenase 1 (Ido1) Inhıbıtors Through Vırtual Screenıng
(Sağlık Bilimleri Enstitüsü, 2024-01-04)Cancer, a leading global cause of deaths, utilizes mechanisms and pathways to evade the immune system, one of which is the kynurenine (Kyn) pathway, responsible for degrading amino acid L-tryptophan (Trp). Overexpression ... -
Evaluatıon of Developmental Toxıcıty of Ethephon Usıng Embryonıc Stem Cell Model
(Sağlık Bilimleri Enstitüsü, 2018-09-19)Mohammadi Nejad S. Evaluation of Developmental Toxicity of Ethephon Using Embryonic Stem Cell Model. Hacettepe University, Graduate School of Health Sciences, Pharmaceutical Toxicology Program, Doctor of Philosophy Thesis, ... -
Farmasötik Preparatlardan ve Gıdalardan Tobramisin Tayini İçin Moleküler Baskılanmış Nanosensörlerin Geliştirilmesi
(Sağlık Bilimleri Enstitüsü, 2013)In this thesis study, the molecularly imprinted glassy carbon and quartz crystal microbalance (QCM) nanosensors were developed for the determination of tobramycin. For QCM nanosensor, firstly the modification of gold surface ... -
Farmasötik Ürünlerde Tüketilebilirlik Çalışmalarına Analitik Yaklaşımlar
(Sağlık Bilimleri Enstitüsü, 2023-12-21)Ignoring the effects of extractable substances not only creates great difficulties for drug manufacturers and regulations, but also changes the safety of the drug due to the dangers that impurities may cause. The suitability ... -
Fenotiyazin Yapılı Bileşiklerin Amiloid Prekürsör Protein ve Amiloid Beta Peptitler Üzerindeki Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2017-09)In the present study, we aimed to investigate the effects of two phenothiazine-structured compounds [toluidine blue O (TBO) and thionine (TH)], which were found to be potent inhibitors of human erythrocyte acetylcholinesterase ... -
Fetal Sığır Serum Asetilkolinesterazının Tetramerik Yapısını Organize Eden Poliprolin Peptidlerin Kütle Spektrometre ile Analizi
(Sağlık Bilimleri Enstitüsü, 2014)Acetylcholinesterase (AChE) in the serum of fetal bovine is a tetrameric enzyme. The related enzyme, butyrylcholinesterase (BChE), in the sera of humans and horse requires polyproline peptides for assembly into tetramers. ... -
Gadoterat Meglumin’in Bozunma Ürünlerinin Varlığında Yüksek Basınçlı Sıvı Kromatografisi ile Analizleri
(Sağlık Bilimleri Enstitüsü, 2023)Gadolinium contrast agents are chemicals used in magnetic resonance imaging. When injected into the body, gadolinium contrast agent enhances and improves the quality of magnetic resonance imaging. These substances are ... -
Glioblastoma Multiforme, Menenjiyom (Birincil) ve Metastaz (İkincil) Beyin Tümörlerine Ait Fenotiplerin Belirlenmesinde Kullanılacak Bütünleşik Omiks Analizler İçin Analitik Yöntem Geliştirilmesi ve Uygulanması
(Sağlık Bilimleri Enstitüsü, 2022)A thorough examination of intermediate molecular levels such as protein, metabolite, and lipid is required to establish direct causal and functional links between genotype and phenotype. Comprehensive metabolomics and ... -
H2 Reseptör Antagonistlerinin Yeşil Hplc Ayırımı İçin Kemometrik Optimizasyon Yaklaşımı ve Famotidin İçeren Farmasötik Preparatlara Uygulanması
(Sağlık Bilimleri Enstitüsü, 2022)H2 receptor antagonists are often preferred in gastroesophageal reflux disease or in the treatment of gastric acidity disorders. In this thesis, an HPLC method for simultaneous analysis of H2 receptor antagonists, famotidine, ... -
HepG2, Caco-2 ve HT-29 Kanser Hücrelerinde 2D Jel Elektroforez ve MALDI-TOF/TOF-MS) ile Ankaferd Hemostat’ ın İn-Vitro Antineoplastik Etkisinin Proteomik Açıdan Araştırılması
(Sağlık Bilimleri Enstitüsü, 2019)One of the breakthroughs in life sciences has been accomplished through the completion of the human genome project. However, the compose of the entire genome map has also brought a tough task for scientists. This task is ... -
Ht29 Ve K562 Kanser Hücrelerinde Protein ve Metabolitlerin Analizi Için Çeşitli Analitik Yöntemlerin Geliştirilmesi
(Sağlık Bilimleri Enstitüsü, 2013)Cancer is one of the most dangerous fatal diseases threating the human being both economically and socially. Therefore, the studies are performed on molecular level to understand cancer on molecular level and prevent the ... -
İnsan Serum Bütirilkolinesterazı ve Eritrosit Asetilkolinesterazının Statin Türevleri ile Etkileşiminin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2014)To investigate effects of statins on cholinesterases, Butyrylcholinesterase (BChE; E.C.3.1.1.8 ) was purified from human plasma through acid dialysis, DEAE-Tris Acryl M ion exchange and Procainamide-Sepharose 4B chromatography ... -
İnsan Serum Bütirilkolinesterazının Karaciğer Hepg2 Hücrelerinde Lipid Metabolizması ile Etkileşiminin İncelenmesi.
(Sağlık Bilimleri Enstitüsü, 2015)Butyrylcholinesterase (BChE) synthesized in liver is mostly associated with the detoxification of xenobiotics. Recently we have shown that in sedentary young males, application of exercise and/or conjugated linoleic acid ...