Biyobozunur Poliüretan Bazlı Sert Doku Malzemelerinin Geliştirilmesi
Özet
It is important to develop hard
tissue support products and innovative biomaterials for bone injuries. In this thesis, it
is aimed to develop biodegradable polyurethane based bone regenerative films as hard
tissue supporting materials. For this purpose, bioactive polyurethane elastomer films
were synthesized by two step condensation polymerization of polycaprolactone diol
and hexamethylene diisocyanate monomers with bioactive chain regulators . Chain
regulators, amino acid molecule L-glutamine, drug active agent metformin and
inorganic compound β-glycerophosphate were integrated in to diisocyanateterminated
polyurethane prepolymer via their difunctional groups. The average
molecular weights of polyurethane-based prepolymers, chemical, thermal,
viscoelastic, mechanical, surface properties and biodegradation behaviors of chain
extended polyurethane films were investigated. The macromolecular structures of
bioactive chain regulator containing polyurethanes had shown chemical differences
due to the presence of urethane, urea hydrogen bonds. Dynamic mechanical analyzes
have shown that polyurethane films possess all the transitions of viscoelastic behavior.
β-glycerophosphate caused decrease in glass transition temperature (Tg), elastic
modulus, ultimate tensile strength and elongation at break point values of
polyurethanes. On the other hand metformin increased Tg temperature and decreased
the mechanical properties of polyurethanes. β-TCP (β-Tricalcium phosphate)
containing polyurethane composites were prepared and their chemical, mechanical,
surface properties and biodegradation behaviors were characterized. β-TCP containing
polyurethane films had shown lower elastic modulus values compared to polyurethane
elastomer films. In this thesis, significant and positive findings were obtained for the
use of the developed biodegradable polyurethane elastomers as bone regenerative film.
