Crystal Structure And Hirshfeld Surface Analysis Of 3,4-Dihydro-2-(2,4-Dioxo-6-Methylpyran-3-Ylidene)-4-(4-Pyridin-4-Yl)-1,5-Benzodiazepine

Abstract

In the title compound, the pendant di­hydro­pyran ring is rotationally disordered in a 90.899 (3):0.101 (3) ratio with the orientation of each component largely determined by intra­molecular N—H⋯O hydrogen bonds. In the crystal, inversion-related mol­ecules form dimers through inter­molecular N—H⋯O hydrogen bonds with the dimers associated along the b-axis direction by slipped π-stacking inter­actions between the pyridyl and di­hydro­pyran rings., The title compound, C20H17N3O3 [systematic name: 2-(6-methyl-2,4-dioxo­pyran-3-yl­idene)-4-(pyridin-4-yl)-2,3,4,5-tetra­hydro-1H-1,5-benzodiazepine], is built up from a benzodiazepine ring system linked to pyridyl and pendant di­hydro­pyran rings, where the benzene and pyridyl rings are oriented at a dihedral angle of 43.36 (6)°. The pendant di­hydro­pyran ring is rotationally disordered in a 90.899 (3):0.101 (3) ratio with the orientation of each component largely determined by intra­molecular N—HDiazp⋯ODhydp (Diazp = diazepine and Dhydp = di­hydro­pyran) hydrogen bonds. In the crystal, mol­ecules are linked via pairs of weak inter­molecular N—HDiazp⋯ODhydp hydrogen bonds, forming inversion-related dimers with R 2 2(26) ring motifs. The dimers are further connected along the b-axis direction by π–π stacking inter­actions between the pendant di­hydro­pyran and pyridyl rings with centroid–centroid distances of 3.833 (3) Å and a dihedral angle of 14.51 (2)°. Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from H⋯H (50.1%), H⋯C/C⋯H (17.7%), H⋯O/O⋯H (16.8%), C⋯C (7.7%) and H⋯N/N⋯H (5.3%) inter­actions. Hydrogen-bonding and van der Waals inter­actions are the dominant inter­actions in the crystal packing.