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dc.contributor.authorSimsek, Fatma
dc.contributor.authorInan, Sevinc
dc.contributor.authorMuftuoglu, Sevda
dc.contributor.authorOzbilgin, Kemal
dc.contributor.authorVatansever, Seda
dc.contributor.authorTuglu, Ibrahim
dc.date.accessioned2021-06-03T06:03:29Z
dc.date.available2021-06-03T06:03:29Z
dc.date.issued2019
dc.identifier.issn2602-3032
dc.identifier.urihttp://dx.doi.org/10.17826/cumj.418346
dc.identifier.urihttp://hdl.handle.net/11655/24178
dc.description.abstractPurpose: The aim of this study was to investigate the effect of propranolol (PR), which is used in infantile hemangiomas, and paclitaxel (PX), which is widely used as an chemotherapeutic agent, on cancer cells. Materials and Methods: That the cells counted with trypan blue the doubling time were determined. Also with MTT assay were analyzed the cytotoxic effect and IC50 value of drugs. In the breast cancer cell lines which are differents with regard to invasion (MDA-MB-231 and MCF-7) anti-VEGF, anti-eNOS, anti-iNOS and anti-ERK1/2 primer antibodies investigated by using immunohistochemical methods. To evaluation of immunoreactivity was used the H-scoring system. Results: With MTT test, IC50 values are applied to the cells dosage for MDA-MB-231 cells; PX: 5 nmol, PR: 50 mu m, and for MCF-7 cells PX: 3,7 nmol, PR: 50 mu m, were established. In immunohistochemical application, immunoreactivity of control group was increased with strong and/or stronger in the cancer cells, while those of in PX, PR and combine treatment was decreased either significant or very significant. Conclusion: With this study, application of anti chemotherapeutic therapy which is paclitaxel, in additon with anti angiogenic therapy in the treatment of breast cancer, vascular vasodilation, cell proliferation, migration, survival ultimately thought to be important in the prevention or reduce of angiogenesis.
dc.language.isotur
dc.relation.isversionof10.17826/cumj.418346
dc.rightsAttribution 4.0 United States
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMCF-7
dc.subjectangiogenesis
dc.subjectMDA-MB-231
dc.subjectpropranolol
dc.titleEffects Of Propranolol And Paclitaxel On Angiogenesis In Breast Cancer Cell Lines
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalCukurova Medical Journal
dc.contributor.departmentHistoloji ve Embriyoloji
dc.identifier.volume44
dc.identifier.issue1
dc.description.indexWoS


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Attribution 4.0 United States
Except where otherwise noted, this item's license is described as Attribution 4.0 United States