Bazı Tiyoüre ve Amit Türevlerinin Sentezi ve Çeşitli Anyonlarla Hidrojen Etkilerinin İncelenmesi

Abstract

Organic compounds are bonded covalently, and these bonds are usually polar covalent bonds. If the bond is formed between two different atoms, the charge distribution(known as the inductive effect) is affected because of the electronegativity difference between two atoms. N-H groups of thioureas, pyrroles, porphyrins, guanidines and conjugated amides can bind anions such as F-, Cl-, Br-, I-, AcO-, HSO4 -, CN- via hydrogen bonding or electrostatic interactions. This phenomenon is defined as anion coordination. The synthesis of this type of compounds are important because the interactions of these compounds with F-, AcO-, H2PO4 - for biomedical researches or interactions with environment sensitive ions such as CN- and NO2 - were not only observed by 1H NMR spectral changes but their striking color changes can also be observed by naked eye. The aim of this study was to synthesize thiourea and amide derivatives by the reactions of acyl chlorides and amines. In the first part of the study, dithiourea and diamide derivatives were obtained from the reactions of benzoyl chloride and oxalyl chloride with mono and diamines. Synthesized products were characterized using by 1H NMR, 13C NMR, MS and FT-IR techniques. In the second part of the study, the interactions between hydrogens of electronegative atom and anions of tetraalkylammonium salts were investigated by using 1H NMR titration technique. Furthermore, the color changes of anion solutions were observed by naked eye.