Non-Segmental Vitiligo ile HLA Genotipi Ve Oksidatif Stres Arasındaki İlişki

Abstract

Vitiligo is an autoimmune skin diseases characterized by acquired loss of functional melanocytes. Although the pathogenesis of vitiligo remains poorly understood, oxidative stress and autoimmune disregulations are considered to play the main role in the apoptosis of melanocytes along with genetic predisposition. The role of HLA in susceptibility to vitiligo has been investigated in Morocco, India and Brazil. Both HLA class I and II alleles were found to increase in vitiligo patients. The aim of this study in to evaluate HLA profile and total antioxidant capacity (TAC) and their relationship to clinical characteristic of vitiligo patients. Ninety-one vitiligo patients and 100 healthy controls were included in the study. Demographic and disease specific features of the patients were recorded. We analyzed HLA frequencies using polymerase chain reaction-sequence-specific primers (PCR-SSO). Serum TAC levels were measured and compared between vitiligo patients and controls. HLA-A*02 allele frequency was increased (OR=2.2, CI=1.2-4.02, p=0.010), HLA-A*11 (0,39, CI=0.17-0.87, p=0.019) and HLA-DRB1*01 (OR=0.39, CI=0.16-0.92, p=0.029) frequencies were decreased in vitiligo patients. HLA-A*02 allele especially increased the risk of late onset (Vitiligo onset >30 years of age) vitiligo (OR:3.67, 95% CI: 1.63-8.26, p=0.002). HLA-A*26 allele was associated with early onset vitiligo, HLA-DQB1*02 and HLA-DRB1*07 alleles were associated with widespread and early onset vitiligo. Serum TAC levels were similar between vitiligo patients and healthy controls and no significant correlation was observed between TAC levels and diseases charecteristics. TAC levels were significantly lower in patients who did not had a HLA-DRB1*01 alelle. Our study showed that HLA-A*02 increases, HLA-A*11 and HLA-DRB1*01 decreases vitiligo susceptibility in Turkish patients as well as a possible relationship between HLA and TAC.