Bazı Yeni 2-Sübstitüe Benzotiyazol Türevlerinin Ames Test Sistemi İle Mutajenik Etkilerinin Belirlenmesi
Özet
In this study, the mutagenic potentials of 15 newly synthesized 2- substituted benzothiazole derivatives those are thougt to have chemotheropatic effect, were investigated by using short time bacterial mutagenicity test system namely Ames test system.In this study Salmonella typhimurium TA98 strain was used to detect frameshift mutagens and S. typhimurium TA100 strain was used to detect for base-pair substitution mutagens. Daunomicina (6 μg plate) was used as a positive control for S. typhimurium TA98 and sodium azide (1,5 μg plate) was used for S. typhimurium TA100.In the cytotoxicity assay 1, 5 and 6 numbered compounds (200 μg plate) and 8 numbered compound (150 μg plate) were found to have cytotoxic effect.
