In Vitro Activity Of A New Echinocandin, Ly303366, Compared With Those Of Amphotericin B And Fluconazole Against Clinical Yeast Isolates

Abstract

The in vitro activity of LY303366, a new echinocandin derivative, was evaluated with 191 yeast isolates by a broth microdilution method. The MICs at which 50% of the isolates were inhibited were 0.125 mu g/ml for Candida albicans and C. tropicalis, 0.25 mu g/ml for C. krusei, C. kefyr, and C. glabrata, and 2.0 mu g/ml for C. parapsilosis.