A Prospective International Aspergillus Terreus Survey: An Efisg, Isham and Ecmm Joint Study

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Date
2017
Author
Risslegger, B.
Zoran, T.
Lackner, M.
Aigner, M.
Sanchez-Reus, F.
Rezusta, A.
Chowdhary, A.
Taj-Aldeen, S. J.
Arendrup, M. C.
Oliveri, S.
Kontoyiannis, D. P.
Alastruey-Izquierdo, A.
Lagrou, K.
Lo Cascio, G.
Meis, J. F.
Buzina, W.
Farina, C.
Drogari-Apiranthitou, M.
Grancini, A.
Tortorano, A. M.
Willinger, B.
Hamprecht, A.
Johnson, E.
Klingspor, L.
Arsic-Arsenijevic, V.
Cornely, O. A.
Meletiadis, J.
Prammer, W.
Tullio, V.
Vehreschild, J. -J.
Trovato, L.
Lewis, R. E.
Segal, E.
Rath, P. -M.
Hamal, P.
Rodriguez-Iglesias, M.
Roilides, E.
Arikan-Akdagli, S.
Chakrabarti, A.
Colombo, A. L.
Fernandez, M. S.
Martin-Gomez, M. T.
Badali, H.
Petrikkos, G.
Klimko, N.
Heimann, S. M.
Houbraken, J.
Uzun, O.
Edlinger, M.
de la Fuente, S.
Lass-Floerl, C.
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Abstract
Objectives: A prospective international multicentre surveillance study was conducted to investigate the prevalence and amphotericin B susceptibility of Aspergillus terreus species complex infections. Methods: A total of 370 cases from 21 countries were evaluated. Results: The overall prevalence of A. terreus species complex among the investigated patients with mould-positive cultures was 5.2% (370/7116). Amphotericin B MICs ranged from 0.125 to 32 mg/L, (median 8 mg/L). Conclusions: Aspergillus terreus species complex infections cause a wide spectrum of aspergillosis and the majority of cryptic species display high amphotericin B MICs. (C) 2017 Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases.
URI
https://doi.org/10.1016/j.cmi.2017.04.012
http://hdl.handle.net/11655/14811
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