Total Parenteral Beslenme (Tpn) Çözeltilerini Hazırlamak İçin Kullanılan Bileşenlerde Ve Tpn Çözeltilerinde Olası Alüminyum Kontaminasyonunun Araştırılması

Abstract

Inorganic toxicity awareness and research has been increasingly echoed in the scientific world with increasing exposure to metals. Aluminum (Al), which is one of the most known metals, has attracted attention with its inability to understand its biological function in the body and its long-term toxicity. Humans are exposed to the aluminum via of environment, industry, food additives, and cosmetic products such as deodorant and daily used tools almost every day. Al can be used for therapeutic purposes in antacids, antidiarrheals and vaccine adjuvants. Al is scientifically accepted as a neurotoxin and it is known to cause bone disease in long-term exposure. Publications associated with Alzeimer's disease and Al, although not enough evidence has been provided, encourages researchers to investigate Al contamination. Al contamination has been known for many years in total parenteral nutritional (TPN) solutions, which are the parenteral solutions that provide basic nutritional intake to individuals who cannot be fully fed orally or enteral. In particular, intensive care patients, premature infants, malnourished and post-operative hospitalized patients are exposed to high levels of Al intravenously, which increases the likelihood of neurological diseases in the long-term exposure. Al quantification analysis in manually prepared TPN solution and biological fluids of patients such as blood and urine, is not yet practiced at hospitals of Turkey. Within the scope of this thesis, it is aimed to investigate possible aluminum contamination in the components used in the preparation of TPN solutions and TPN solutions prepared the Pharmacy Unit of Hacettepe University’s Hospital. Samples were analyzed by spectrofluorometric method and it was investigated whether the obtained data were in compliance with the current limits. In addition, this study is thought to be the first link of studies to investigate the relationship between Al toxicity and patients receiving long-term TPN.