Dosya Biçimi"Bilimsel Araştırma Projeleri KB" Enstitüler için listeleme
Toplam kayıt 65, listelenen: 1-20
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ADAM19, FAM13A, IREB2 Genleri Yaygın Varyantlarının KOAH Yatkınlığı ve Şiddeti ile İlişkisi
(Sağlık Bilimleri Enstitüsü, 2022)Chronic obstructive pulmonary disease (COPD) is a heterogenous disease characterized by persistent airway limitation caused by both genetic predisposition and environmental factors. In this study, we aimed to investigate ... -
Adenozin Tayinine Yönelik Optik Temelli Nanosensörlerin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2022-01)In this thesis, a novel measurement method is proposed to measure the level of adenosine nucleoside which is a significant molecule utilized as a direct or indirect indicator to detect diseases such as neurodegenerative ... -
Akciğer Havayolu Modellemesine Yönelik Oluşturulan Deselülerize Doku İskeleleri ile 3b Hücre Kültür Sistemlerinin Kurulması
(Fen Bilimleri Enstitüsü, 2021)The lungs have the task of providing the necessary oxygen for the cells and carrying out the carbon dioxide formed as a result of metabolic events. During this process, which we call breathing, the lungs encounter many ... -
Aml Hastalarında Nkp30 Ve B7-H6, Gal-3, Bag6 Ekspresyon Düzeyleri İle Nk Hücre Sitotoksitesi Arasındaki İlişki
(Kanser Enstitüsü, 2020-01-10)ABSTRACT Aydın,B. The relationship between NKp30 and B7-H6, Gal-3, BAG6 expression levels and NK cell cytotoxicity in AML patients. Master of Science Thesis of Hacettepe University Graduate School of Health Sciences ... -
Anadolu'daki Nadir Otoinflamatuvar Hastalıklar ile İlişkili Mutasyonlar için Alel Yaşının Hesaplanması
(Sağlık Bilimleri Enstitüsü, 2024)Autoinflammatory diseases are diseases that emerge from the abnormalities in the innate immune system of the individuals. In the crisis times, one of the mostly seen symptom is the high amount of inflammation biomarkers. ... -
Anti-Her2 SCFV Antikor Fragmanının Escherichia coli Bakterisinde Üretim Bölgesinin Optimizasyonu
(Fen Bilimleri Enstitüsü, 2022)Antibodies and antibody fragments are used in the diagnosis, imaging, and target-specific treatments of various diseases such as cancer and viral infections. It also has an important place in combating infectious diseases. ... -
Antitrombojenik Nanokompozit Kalp Kapakçık Malzemelerinin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2021)The aim of the thesis is to develop composite scaffolds with antithrombogenic properties and high blood compatibility by modifying decellularized pericardial tissue with carboxylated carbon nanotubes and to characterize ... -
Baş Boyun Kanserli Hastaların Tükürük Örneklerinden İzole Edilen Eksozom ve Bakterilerin, Sağlıklı Kemik İliği Mezenkimal Kök Hücreler Üzerine Etkilerinin Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2022-01-25)Recently, in the development of head and neck cancers, the components, which are responsible for the interaction between cells and surrounding healthy tissues, in the tumor microenvironment have become a burgeoning area. ... -
Deneysel İskemik İnme Modelinde Oksidatif Hasarın Hücresel Düzeyde İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2019-11)The aim of this study is direct intravital monitorization of the pharmacological effects of two well-known neuroprotectant antioxidant molecules having different blood-brain barrier (BBB) permeability against ischemia/reperfusion ... -
Erişkinlerde İnflamatuvar Barsak Hastalığı Ve Çölyak Hastalığı Tanıları İle İzlenen Hastalarda LRBA (Lps-Responsive Beige-Like Anchor) Eksikliği İle İlişkili Primer İmmün Yetmezlik Varlığının Araştırılması
(Çocuk Sağlığı Enstitüsü, 2020-12)In the present study, it was aimed to investigate the presence of the primary immunodeficiency disorder associated with LRBA deficiency in adult patients followed-up with diagnosis of inflammatory bowel disease (IBD) and ... -
Farklı Aktivasyon Basamaklarına İlerletilen Yardımcı T Hücrelerinde Adezyon ve Migrasyon Mekanizmalarının İncelenmesi
(Kanser Enstitüsü, 2020)When different analog T lymphocyte profiles are examined in cancer and chronic infections, these cells can be divided into two subgroups with functional and dysfunctiononal characterization. Naive T lymphocytes which are ... -
Fındık Alerjeninin Çapraz Kontaminasyon Yolaklarının Değerlendirilmesi
(Sağlık Bilimleri Enstitüsü, 2020-01-28)Cross-contamination is a major source of hidden allergens in foods and can occur at all food processing stages. The aim of this study was to investigate contamination pathways and the contamination levels of hazelnut ... -
Geliştirilen Üç Boyutlu Böbrek Proksimal Tübül Modelinde Nefrotoksisite Değerlendirmesi
(Fen Bilimleri Enstitüsü, 2023)Acute kidney injury (AKI) is an important health problem causes the death of 2 million people worldwide every year with high morbidity and mortality. One of the important causes of AKI is drug-induced nephrotoxicity. After ... -
Glikojenin İskemik İnme ve Retinal İskemi Üzerine Olan Etkilerinin Nörogliovasküler Seviyede İncelenmesi
(Nörolojik Bilimler ve Psikiyatri Enstitüsü, 2020-01-16)Ischemic stroke results in sudden blood flow cessation thus leads to sudden onset unmet energy requirements. Although the clotted artery is recanalized and blood flow is restored back, brain perfusion may not be sustained ... -
Hasarlı Omurilik Onarımı İçin Hücre Destekli Enjekte Edilebilir İpek Fibroin Mikrotaşıyıcıların Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2023-09)According to the data of the World Health Organization (WHO), spinal cord injuries affect between 250,000 and 500,000 people every year. In current clinical practice, there is no treatment method that can completely ... -
Havayolu Modellemesi Amaçlı Tasarlanan Mühendislik Ürünü 3B Hücre Kültür Sistemlerinin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2022-06)Chronic airway diseases have a complex set of mechanisms in which environmental and genetic factors play a role. It is very important to study the molecular pathologies of these diseases and to establish suitable cellular ... -
HER2 EKSPRESYONU OLAN MEME KANSERİ HÜCRELERİNDE ÖKARYOTİK ELONGASYON FAKTÖR-2 KİNAZ (eEF2K) AKTİVASYONUNUN ROLÜ
(Kanser Enstitüsü, 2021-06-22)Continuous activation of HER2 leads to the deregulation of various biological responses such as cell proliferation, survival, and migration, and tumor growth. eEF2K is a protein kinase involved in the regulation of protein ... -
Hücre Ölüm Yolaklarının Tespiti İçin Kağıt Tabanlı Biyosensör Tasarımı
(Fen Bilimleri Enstitüsü, 2021)The aim of the presented thesis, a paper-based biosensor design has been designed to be used in the detection of early (extrinsic pathway) and late (instrinsic pathway) stages of apoptosis. In the study, in order to ... -
İlaç Araştırmaları İçin 3-Boyutlu Mikroakışkan Damar Modelinin Geliştirilmesi
(Fen Bilimleri Enstitüsü, 2021)There is a need for a 3-dimensional (3D) vessel model that can be used to simulate in vivo vessel physiology, anatomy, and blood flow-induced fluid tension force that can be used in the investigation of vascular diseases, ... -
İnsan somatik hücrelerinin uyarılmış plüripotent kök hücrelere yeniden programlanması sürecinde arilhidrokarbon reseptörü sinyalizasyonundaki değişimlerin incelenmesi
(Sağlık Bilimleri Enstitüsü, 2023)Sevindi S., Investigation of Changes in Arylhydrocarbon Receptor Signaling in the Reprogramming of Human Somatic Cells into Induced Pluripotent Stem Cells, Hacettepe University Graduate School of Health Sciences Department ...