Bazı Gentiana Türleri Üzerinde Farmakognozik Araştırmalar

Abstract

The genus Gentiana (Gentianaceae) consists species with important phytochemical properties and have been widely used in traditional folk medicine. Iridoids, secoiridoids, C-glycosylflavones and xanthones are considered as the most promising groups of compounds responsible for the pharmacological activities of the species. Moreover, they are also evaluated as the important key compounds in the aspect of chemotaxonomy of the genus Gentiana. The aim of this thesis, which was planned as a continuation of our previous studies on Gentiana species in our department, was to identify the chemical composition as well as MAO-A enzyme inhibition activities of the overground parts of Gentiana pyrenaica, G. verna subsp. balcanica and G. verna subsp. pontica, growing on Uludağ (Bursa) and Zigana Mts. (Trabzon). n-buthanol extracts of the over ground parts of the title plants were prepared and the MAO-A inhibitory activity of these extracts were tested. By means of chromatographic studies on the H2O extracts a new secoiridoid glucoside, three new benzophenone glucosides in addition to two xanthone glucosides were isolated from G. verna subsp. pontica; and a flavon Cglucoside and two simple phenolic glucosides were isolated from G.pyrenaica. Chemical composition of G. verna subsp. balcanica were analyzed by using an HPLC method. Gentiana pyrenaica, G. verna subsp. balcanica and G. verna subsp. pontica and two benzophenone glucosides were found to possess MAO-A inhibitory activity.