Bazı 2-(4-Sübstitüe)Fenil-5-Benziliden P-Sübstitüebenziliden-3-Fenilaminotiyazolidin-4-On Türevleri Üzerinde Çalışmalar

Abstract

In this study, 2 new compunds having 3- (phenylamino)-2-[4-(1H-1,2,4-triazole/imidazolyl)phenyl]-1,3-thiazolidin-4-one (Compounds 1,2) and 9 new compounds having 5-(benzylidene/-psubstitutedbenzylidene)- 3-(phenylamino)-2-[4-(1H-1,2,4-triazolyl/imidazolyl) phenyl]-1,3-thiazolidin-4-one structures were synthesized and evaluated for their antimycobacterial activities against M. tuberculosis H37Rv. Our target compounds were obtained by a series of reaction starting from 4-(1H-1,2,4- triazole/imidazole-1-yl)benzaldehyde derivatives. The structures of synthesized compounds were proven by IR, 1H-NMR, mass spectra and elemental analysis data. According to activity results, none of the target compounds were found as active as isoniazid, rifampin, ethambutol and ciprofloxacin, standard compunds. However, in both imidazole and triazole containing compounds, benzylidene substitution increased antimycobacterial activity. Considering the effects of the substituents on the benzylidene ring to the activity, nonsubstituted derivatives (Compounds 3, 8) were found more effective than the substituted ones and substitution on the benzylidene ring decreased activity (except Compound 10).