Bölüm "Tıbbi Biyoloji" için listeleme
Toplam kayıt 75, listelenen: 1-20
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A Comparison of Different Irrigation Systems and Gravitational Effect on Final Extrusion of the Irrigant
(2015)Background The aim of this study was to compare manual needle irrigation (MNI), RinsEndo (RE), and passive ultrasonic irrigation (PUI), and assess the effect of gravity on extrusion from the apex in vitro. Material and ... -
AEBP1/ACLP'nin Protein Etklileşim Ağının Proteomik ve Biyoinformatik Yöntemlerle Araştırılması
(Sağlık Bilimleri Enstitüsü, 2020)Extracellular Matrix (ECM) is the mechanical supportive structure for cells and tissues. Chronic damage may cause loss of ECM integrity that may result in fibrosis which is the progressive and irreversible accumulation of ... -
Ailevi Akdeniz Ateşi (AAA) Hastalığında Belirlenen Aday miRNA'ların Dolaşımdaki Varlığının Eksozomlar Üzerinden Araştırılması
(Sağlık Bilimleri Enstitüsü, 2018)Familial Mediterranean Fever (FMF) is inherited in an autosomal recessive manner. FMF is a monogenic disease however, phenotypic heterogeneity can be seen in different patient groups. Epigenetic factors including miRNAs ... -
Ailevi Akdeniz Ateşi Hastalığında Görülen İnflamasyon Sürecinde Rol Alan Mirna'ların Tanımlanması
(Sağlık Bilimleri Enstitüsü, 2018-09-24)Familial Mediterranean Fever (FMF); is an autosomal recessively inherited autoinflammatory disease. FMF is caused by the mutations in the Mediterranean Fever (MEFV) gene which encodes the pyrin protein. The best treatment ... -
Alzheimer Hastalığı’nın Beyin Anjiyotensin Reseptörleri ile İlişkisi ve Anjiyotensin Reseptör Blokörlerinin Bu İlişkiye Etkisi
(Sağlık Bilimleri Enstitüsü, 2023)Alzheimer's disease (AD) is a neurodegenerative disease, that is characterized by a decline in cognitive function, and whose etiology is not yet fully understood. Recently, it has been shown that the incidence of AD is ... -
Aryl Butenoic Acid Derivatives As A New Class Of Histone Deacetylase Inhibitors: Synthesis, In Vitro Evaluation, And Molecular Docking Studies
(Scientific Technical Research Council Turkey-Tubitak, 2014)New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group, with a double bond in the short linker as well as metal binding groups, enoic ester, ... -
Assignment of a Form of Congenital Muscular Dystrophy with Secondary Merosin Deficiency to Chromosome 1Q42
(Univ Chicago Press, 2000)We have previously reported an autosomal recessive form of congenital muscular dystrophy, characterized by proximal girdle weakness, generalized muscle hypertrophy, rigidity of the spine, and contractures of the tendo ... -
Association of Cystic Fibrosis Genetic Modifiers with Congenital Bilateral Absence of the Vas Deferens
(Elsevier Science Inc, 2010)Objective: To investigate whether genetic modifiers of cystic fibrosis (CF) lung disease also predispose to congenital bilateral absence of the vas deferens (CBAVD) in association with cystic fibrosis transmembrane conductance ... -
Carboxylic Acid Derivatives of Histone Deacetylase Inhibitors Induce Full Length Smn2 Transcripts: A Promising Target For Spinal Muscular Atrophy Therapeutics
(2011)Introduction Proximal spinal muscular atrophy (SMA) is a common autosomal recessively inherited neuromuscular disorder. It is caused by homozygous absence of the survival motor neuron 1 (SMN1) gene. SMN2, which modulates ... -
Class I Histone Deacetylase Inhibition By Aryl Butenoic Acid Derivatives: In Silico And In Vitro Studies
(2019)Histone deacetylases (HDAC) are evolutionary conserved enzymes, which catalyze removal of acetyl groups from histone and non-histone proteins, therefore, control multiple biological processes. Inhibition of their activities ... -
Clinical Long-Time Course, Novel Mutations And Genotype-Phenotype Correlation In A Cohort Of 27 Families With Pomt1-Related Disorders
(2019)Background The protein O-mannosyltransferase 1, encoded by the POMT1 gene, is a key enzyme in the glycosylation of α-dystroglycan. POMT1–related disorders belong to the group of dystroglycanopathies characterized by a ... -
Comparison Of Intravenous Versus Intraperitoneal Interleukin-10 Gene Delivery In Mouse Model Of Sepsis
(Kafkas Univ, Veteriner Fakultesi Dergisi, 2013)The most novel approach utilizing IL-10 in sepsis is IL-10 gene delivery in experimental model of sepsis. In our study, we aimed to compare kinetics of intravenous versus intraperitoneal delivery of IL-10 gene transfer in ... -
Desma Mutant Zebra Balığı Modelinde Tedavi Amaçlı Xmu-Mp-1 Uygulaması
(Sağlık Bilimleri Enstitüsü, 2021)In this thesis, the application of XMU-MP-1 drug candidate molecule which is a MST1 / 2 kinase inhibitor and selectively inhibits the Hippo pathway was performed by mixing the drug with zebrafish embryo egg water or adult ... -
Desma ve Desmb Knockout Zebra Balığı Modellerinde Desmin İfadesinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2017)Desmin, a basic intermediate filament protein specific to muscle tissue, facilitates the transmission of force during muscle contraction and relaxation by forming a large network structure that allows the myofibrils to ... -
Desmin ve Lamin B Etkileşiminin Zebra Balığında Araştırılması
(Sağlık Bilimleri Enstitüsü, 2017)In this thesis the interaction between desmin, an intermediate filament protein located in cytoplasm and lamin B, intermediate filament protein of the nucleus was investigated using wild type AB zebrafish as a model ... -
Desminin çekirdeğe taşınımının potansiyel mekanizmalarının araştırılması
(Sağlık Bilimleri Enstitüsü, 2024)Kural Mangıt E., Investigation of Potential Mechanisms for Nuclear Transport of Desmin. Hacettepe University, Graduate School of Health Sciences, Ph.D. Thesis in Medical Biology, Ankara, 2024. Studies have shown that ... -
Diyabet Hastalarında Mineral Trioksit Agregat/1α,25-Dihidroksivitamin D3 Kombinasyonu İle Dental Pulpa Kök Hücrelerinde Odontojenik Farklılaşmanın Araştırılması
(Sağlık Bilimleri Enstitüsü, 2021-01-15)Dental treatments in diabetic patients have been reported to fail in the long term and these patients have more tooth extraction. It is aimed to investigate the odonto/osteogenic differentiation potential of the combination ...