Gastroenteropankreatik Nöroendokrin Tümörlerin Klinikopatolojik Özelliklerinin Incelenmesi

Abstract

Gastroenteropancreatic neuroendocrine tumors (GEP-NET) are a heterogenous group of neoplasm originating from the neuroendocrine system of the gastrointestinal tract and pancreas. There aren't many large well-designed studies investigating NETs in Turkey. The aim of this study is to define the clinicopathologic, demographic and survival features of patients with GEPNETs. Methods: In this study, we reviewed hospital records of patients. The data was analyzed retrospectively and we investigated clinical, pathological and survival features and prognosis of patients with GEP-NETs (n=128) admitted to Hacettepe University Medical Faculty, Medical Oncology Department between 2003 and 2014. Survival curve estimation was performed using the Kaplan-Meier method. Results: The median age of patients was 51.5 (17-81). Among 128 patients with GEP-NETs 61 (47.7%) were female and 67 (52.3%) were male. The most common site of tumor was stomach (36.7%). There were 91 (71.1%) NET patients originating from foregut, 20 (15.6%) from midgut and 9 (7.0%) from hindgut. Six patients had unknown primary site NET (UPS) with metastasis. The most common stage at diagnosis was stage 4 (40.9%). The most common grade was grade 1 (56.8%). 70.3%of patients had curative surgery. The median follow-up period was 37 months. Three-years overall survival rate was 78%, while 5 years overall survival rate was 69%. The factors that can significantly affect the overall survival rate were stage (p=0.003), grade (p<0.001), presence of metastasis (p<0.001) and Ki-67 proliferation index (p=0.001) and these factors were asscociated with 3 and 5 years overall survival rate. Conclusion: Overall survival was found to be related to stage, grade, distant metastasis at diagnosis and Ki-67 proliferation index.