Neodymium:Yttrium-Aluminum-Garnet Lazer ve Fraksiyonel Karbondioksit Lazerin Saçlı Deride Yerleşen Alopesi Areata'daki Etkilerini Araştıran Karşılaştırmalı ve Kontrollü, Prospektif Klinik Çalışma
Özet
Alopesi areata (AA) is an autoimmune disease that causes hair loss. There is a need for effective and safe treatment options. Whether lasers might be a treatment option for alopecia is a topic of debate. This comparative, controlled, prospective clinical trial was designed to test the hypotheses that Nd:YAG and fractional carbon dioxide lasers might stimulate development of new hair on the scalp of AA patients. Three patches for each 32 patients whose mean age was 24,22±10,26 years, range (10-49 years) with a median SALT score of 28%, range (3-100%), who had at least 2 years of disease duration and/or who has not responded at least 2 of the standard treatments, were recruited for the study. Of the 3 different patches selected on the patients’ scalp, Nd:YAG laser (Laserscope LyraiTM, with a pulse duration of 30 ms and a dose of 10 joule/cm2) was applied to the first patch, whereas fractional laser (Lutrionic, eCO2TM, with a dose range of 10-45 milijoule/cm2, 30 watt, 120 μm probe diameter) was applied to the second patch, with an application interval of 2-8 weeks and for a total of 2-6 sessions. The third patch was determined as the control patch and no laser application was made. The mean outcome measure was the hair count which was calculated with a digital phototrichogram. Initial hair counts for all three patches were similar. After a mean follow-up of 3,25±1,48 months, median 3 months, range (2-6 months) period, there was no statistically significant increase in the mean hair count for the 3 patches (p values for Nd:YAG and Fractional lasers are p=0,4 and p=0,17, respectively). Power of this study in excluding both hypotheses was found as 99%. Results of this study revealed that Nd:YAG and fractional carbon dioxide lasers could not be treatment alternatives for AA, with the laser parameters used in this study.
