IGA Nefropatili Çocukların Uzun Süreli Seyrinin Değerlendirmesi

Abstract

Immunglobulin A (Ig A) nephropathy is one of the most frequent reasons of primary glomerulonephritis. Clinically it ranges from asymptomatic hematuria to rapidly progressive glomerulonephris. There is no specific clinical feature and absolute diagnosis is possible histopatologically. Long term studies showed that 20 % of children with Ig A nephropaty developed end stage renal failure. In this study we aimed to determine clinical progression of patients who were diagnosed as Ig A nephropaty and treated in Hacettepe University Ihsan Dogramaci Pediatric Hospital Pediatric Nephrology Department. 19 pediatric patients who were diagnosed as Ig A nephropaty after renal biopsy and after ruling out any secondary reasons and followed at least 12 months between 2003 and 2012 were included in the study. Data was collected at first administration, 12th month and at last visit. We compared patients' last clinical and laboratory results with first ones. By this way patients' response to therapy and clinical progression were evaluated. Data showed that most frequent symptom was hematuria. Proteinuria values were variable. Hypertension as a prognostic feature was not observed any af our patients. There were no significant difference between three time points in proteinuria and pathology results in statistical analysis. But there was significant difference in e-GFR values between time points. There was no significant difference in proteinuria after different treatment regimens between time points. After all regimens it was obvious that decline in proteinuria. In our country there is no enough broad clinical study about clinical progression of pediatric patients with Ig A nephropaty so we aimed to help in this lack.