Türkiye'de Menenjite Neden Olan Bakteriyel Ajanlar ve Meningokokal Serogrupların Seroprevalansı

Abstract

Successful vaccination policies for protection from bacterial meningitis are dependent on determination of the etiology of bacterial meningitis. During 2009-2011, cerebrospinal fluid (CSF) samples were obtained prospectively from children (1 month – ≤ 18 years of age) with suspected meningitis, in order to determine the etiology of bacterial meningitis in Turkey. DNA evidence of Neisseria meningitidis (N. meningitidis), Streptococcus pneumoniae (S. pneumoniae), and Haemophilus influenzae type b (Hib) was detected using multiplex polymerase chain reaction (PCR). In total 500 CSF samples were collected and bacterial etiology was determined in 109 cases; N. meningitidis was detected in 65.1 %, S. pneumoniae in 30.3 %, and Hib in 4.6 %of the PCR positive samples. Of the N. meningitidis positive samples, 58 %, 22 %, and 6 %belonged to serogroups W135, A, and B, respectively, while 14 %were non-groupable. These results highlight the need for broad based protection against meningococcal disease in Turkey.