Overin Müsinöz Tümörlerinde Pax2, Pax8 ve Cdx2 Ekspresyonu: Metastaz Ayırıcı Tanısı ve Patogenezdeki Yeri

Abstract

Ovarian cancer is the most common cause of gynecologic cancer death. Both morphologically and immunohistochemically, metastatic mucinous tumors are the best mimickers of mucinous ovarian tumors; its pathogenesis still remains a mystery. PAX2 and PAX8 immunohisyochemistries are useful for differentiating numerous primary tumour types from metastatic ones. There are fewstudies in literature about PAX expressions in mucinous tumors. None of these are takes into account the histologic type (whether it is seromucinous or intestinal) or the metastatic origin. With this purpose hematoxylin and eosine slides of ovarian mucinous tumors were re-evaluated and one block was chosen for each case. The study included 76 ovarian mucinous tumors of the ovary reported in Hacettepe University department of pathology between 2000-2013. Tissue microarray (TMA) was designed from the chosenblocks, PAX2, PAX8, CDX2 immunostains was preformed to the TMA slides. As a result, most of the metastatic cases (%80-90) were negative for PAX2 and PAX8, many (%65-75) were diffusely and strongly positive for CDX2. Seromucinous tumors were devoid of CDX2 expression; but all cases (except one) displayed strong and diffuse positivity with PAX8. In other words differing from intestinal mucinous tumors seromucinous tumors show strong PAX8 positivity–similar to serous tumors-This study shows that PAX8 and CDX2 could be useful in differentiating primary mucinous from metastatic tumor. Furthermore unlike the homogeneity in seromucinous tumors for PAX-8 and CDX2 intestinal type shows heterogeneity with different expression patterns.