Dosya Biçimi"Bilimsel Araştırma Projeleri KB" Temel Tıp Bilimleri Bölümü Tez Koleksiyonu için listeleme
Toplam kayıt 74, listelenen: 1-20
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AEBP1/ACLP'nin Protein Etklileşim Ağının Proteomik ve Biyoinformatik Yöntemlerle Araştırılması
(Sağlık Bilimleri Enstitüsü, 2020)Extracellular Matrix (ECM) is the mechanical supportive structure for cells and tissues. Chronic damage may cause loss of ECM integrity that may result in fibrosis which is the progressive and irreversible accumulation of ... -
Ailevi Akdeniz Ateşi Hastalarında Otoenflamasyonun İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2023)Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease. The aim of this study is to determine the changes of GSDMD, IL-1B, and IL-18 in disease attacks of FMF and to compare their levels in the ... -
Allojenik Mezenkimal Kök Hücre Eksozomlarının Üç Boyutlu Mikroakışkan Proksimal Tübül Platformundaki İskemik Akut Böbrek Hasarında Terapötik Etkilerinin Değerlendirilmesi
(Tıp Fakültesi, 2022-05)Cam SB, The Assessment Of The Therapeutic Effects of Allogeneic Human Mesenchymal Stem Cell Exosomes on Ischemic Acute Kidney Injury Model Constituting Three Dimensional Microfluidic Proximal Tubule-On-A-Chip Platform, ... -
Antioksidan Kullanımının Meme Kanseri Tedavisi Üzerindeki Etkilerinin Araştırılması
(Sağlık Bilimleri Enstitüsü, 2021-01-20)Drug resistance against chemotherapy is one of the main factors limitating the success of cancer treatment. Several studies have reported that the expression level of the glutathione S-transferase P1 (GSTP1) isozyme from ... -
Behçet Hastalığına Özgül Otoantikor Varlığının Taranmasına Yönelik Yaklaşımların Geliştirilmesi
(Sağlık Bilimleri Enstitüsü, 2024-10-11)Behçet's disease is a recurrent autoimmune and autoinflammatory disorder that affects the skin, mucous membranes, eyes, joints, gastrointestinal system, and central nervous system. The epidemiology of Behçet's disease varies ... -
Bisfenol A’nın Hepg2 Hücrelerine Olan Etkilerinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2020)Öz, E. Examination of the Effects of Bisphenol A on HepG2 Cells. Hacettepe University Graduate School of Health Sciences, Biochemistry Program, Master Thesis, Ankara, 2020. In this study, it was aimed to determine the ... -
Büyüme Çağındaki Sıçanlarda Oral Kaprilik Asit Uygulamasının Açil Ghrelin ve Büyüme Hormonu Düzeyleri ile Anksiyete Üzerine Etkisi
(Tıp Fakültesi, 2022)Caprylic acid is a medium chain fatty acid containing 8 carbons. Caprylic acid is necessary for the conversion of ghrelin which is known as the hunger hormone, to its active form acyl ghrelin. In addition to its functions ... -
Deneysel Parkinson Hastalığı Modelinde Mitokondri Transplantasyonu ve Egzersizin Etkilerinin Karşılaştırılması
(Sağlık Bilimleri Enstitüsü, 2024-10-11)Parkinson's disease (PD) is associated with degeneration of dopamine-secreting neurons in the brain. PD manifests itself with impaired locomotor and spontaneous activities, such as difficulty initiating movement, tremors, ... -
Deneysel Parkinson Hastalığı Modelinde Obezitenin Motor Becerilere Etkisi ve Beyin Tirozin Hidroksilaz Düzeyi, Dopaminerjik Reseptörler ve Leptin Reseptörleri ile İlişkisinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2023-03)Excessive increase in body weight, which has already become a public health problem, is also associated with many diseases. On the other hand, prolonged life expectancy also increases the incidence of neurodegenerative ... -
Desma Mutant Zebra Balığı Modelinde Tedavi Amaçlı Xmu-Mp-1 Uygulaması
(Sağlık Bilimleri Enstitüsü, 2021)In this thesis, the application of XMU-MP-1 drug candidate molecule which is a MST1 / 2 kinase inhibitor and selectively inhibits the Hippo pathway was performed by mixing the drug with zebrafish embryo egg water or adult ... -
Determination of Lipid Metabolism Alterations and Their Association with Disease Pathogenesis in Sickle Cell Disease
(Sağlık Bilimleri Enstitüsü, 2020-07-07)Sickle cell disease (SCD) is a hemoglobinopathy that causes severe anemia and is characterized by lipid abnormalities, oxidative stress and chronic inflammation. It is caused by a single point-mutation in the beta globin ... -
Diyabet Hastalarında Mineral Trioksit Agregat/1α,25-Dihidroksivitamin D3 Kombinasyonu İle Dental Pulpa Kök Hücrelerinde Odontojenik Farklılaşmanın Araştırılması
(Sağlık Bilimleri Enstitüsü, 2021-01-15)Dental treatments in diabetic patients have been reported to fail in the long term and these patients have more tooth extraction. It is aimed to investigate the odonto/osteogenic differentiation potential of the combination ... -
Doksorubisin Uygulanan Üçlü Negatif Meme Kanserinde Taurinin Tümör Büyüklüğü ve Metastaz Üzerine Etkisi
(Sağlık Bilimleri Enstitüsü, 2023)Gedikli, E., The Effect of Taurine on Tumor Size and Metastasis in Triple Negative Breast Cancer Treated With Doxorubicin, Hacettepe University Graduate School of Health Sciences Physiology Program PhD Thesis, Ankara, 2023. ... -
Dışkı ve Mide Biyopsi Örneklerinden Helıcobacter Pylorı Enfeksiyonunun ve Klaritromisin Direncinin Moleküler Yöntemler ile Saptanması
(Tıp Fakültesi, 2022)Inal Neşe, Detection of Helicobacter pylori Infection and Clarithromycin Resistance in Stool and Gastric Biopsy Samples by Molecular Methods, Hacettepe University Faculty of Medicine, Department of Medical Microbiology, ... -
Endometrial Stromal Hücrelerde Ovaryan Hormonlar ile CKAP4 İlişkisinin İncelenmesi
(Tıp Fakültesi, 2023)Endometrial stromal cells undergo changes in the menstrual cycle and decidualization with the effect of ovarian hormones. Disruptions in these processes may result in clinical outcomes such as infertility, recurrent pregnancy ... -
ENERJİ STRESİNDE GRANÜLOZA HÜCRELERİNİN ACE2 İFADELENMESİNİN SIRT1 İLE İLİŞKİSİNİN DEĞERLENDİRİLMESİ
(Tıp Fakültesi, 2024)Nikshiqi Erblina, Evaluation of the Relationship Between ACE2 Expression and SIRT1 in Granulosa Cells Under Energy Stress, Hacettepe University Faculty of Medicine, Department of Histology and Embryology Residency Thesis, ... -
Evaluation of Recombinational Dna Damage Response in Castration-Resistant Prostate Cancer and Investigation of the Combined Effect of Rad51 And Wee1 Inhibitors on Radiosensitivity
(Sağlık Bilimleri Enstitüsü, 2014-09)Castration-resistant prostate cancer (mCRPC) is a disease with a poor prognosis. Recently, DNA repair mechanisms have been targeted in new treatment regimens, in particular inpatients carrying mutations in the genes of DNA ... -
Farklı Dozlarda ve Sükrozla Birlikte Uygulanan Kakaonun (Theobroma Cacao) Sıçanlar Üzerindeki Anksiyolitik Etkisinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2023)Anxiety disorder is a common condition. The effectiveness of current pharmacological treatments is delayed and their side effects negatively impact patients. Therefore, patients turn to different products. Cocoa is a ... -
Fenilketonüride Öğrenme Bellek Mekanizmasının Dişi Ve Erkek Sıçanlarda cAMP/PKA/CREB/BDNF Yolağı Üzerinden İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2020)Phenylketonuria is a rare hereditary metabolic disease characterized by deficiency of phenylalanine hydroxylase. The absence of enzyme causes blood phenylalanine levels to rise. If patients are not treated, irreversible ... -
FF-MAS Oksisterolünün Folikülogenezdeki Rolünün ve Hedgehog Sinyal Yolağıyla İlişkisinin İncelenmesi
(Sağlık Bilimleri Enstitüsü, 2021-04-29)FF-MAS oxysterol is a derivative of steroid, found in follicular fluid and involved in oocyte maturation. Hedgehog pathway is one of the many cell signaling mechanisms effective in cell proliferation and its effect on the ...
