Karbonmonoksit Zehirlenmesi Olan Çocuklarda Oksidan ve Antioksidan Parametrelerin Değerlendirilmesi

Abstract

Carbon monoxide (CO) is a colourless, smell-free, toxic gas. Carbon monoxide poisoning (COP) is one of the most important causes of morbidity and mortality. The balance between the production of free radicals and antioxidant defenses in the body has important health implications; if there are too many free radicals or too few antioxidants for protection, a condition of oxidative stress develops, which may cause chronic and permanent damage. As in many other diseases, in pathophysiology of COP, oxidative stress plays a certain role. In this study, we aimed that to investigate oxidative stress through the analysis of 8-hydroxy deoxyguanosine (8-OHdG), plasma protein carbonyl (PK), plasma malondialdehyde (MDA) and to evaluate antioxidant defense system by analyzing erythrocyte glutathione (GSH), superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) levels. In addition, we aimed that to study associations between these results and clinical, laboratory aspects and treatment options of patients presenting with CO poisoning. This prospective study was held in Hacettepe University Ihsan Dogramaci Children’s Hospital, Pediatric Emergency Department. Patients, aged between 0-18 years, with acute CO poisoning were included. Without any changes in the management of these patients, blood and urine samples were collected right before and after treatment. Plasma MDA levels were found to be significantly higher in the study group when compared with the control group (p=0.019). No statistically significant differences between before and after treatment analysis except for catalase activity (only in group of normobaric oxygen treatment) were found in either normobaric oxygen treatment group or hyperbaric oxygen treatment group. Enzymatic activity of catalase was significantly decreased after normobaric oxygen therapy. This study showed that CO poisoning is associated with increased lipid peroxidation in children immediately after poisoning. However, treatment modalities do not have a significant effect on oxidative stress or antioxidant parameters.