Anne ve Kordon Kanında Organoklorin Pestisit Düzeylerinin Belirlenerek Annenin Biyokimyasal Parametreleri ve Yenidoğan Üzerindeki Etkilerinin Araştırılması

Abstract

Due to their environmental and biological long half-lives, it is known that banned organochlorine pesticides are still present in every corner of the world and human exposure persists. In this study, determination of hexachlorobenzene (HKB), p,pdichlorodiphenyldichloroethylene (p,p’-DDE), p,p-dichlorodiphenyltrichloroethane (p,p’-DDT) and o,p’-DDT, organochlorine pesticides in maternal (n=76) and cord (n=76) blood was determined with gas chromatograph-mass spectrometry. For HKB, mean was 31.53 ng/mL in maternal blood, 26.5 ng/mL in cord blood; for p,p’-DDE, 17.02 ng/mL in maternal blood and 14.53 ng/mL in cord blood; for p,p'-DDT, 60.56 ng/mL in maternal blood, 55.03 ng/mL in cord blood and for o,p'-DDT, 13.33 ng/mL in maternal blood, 13.4 ng/mL in cord blood. Mothers’ demographic characteristics, babys’ birth information, maternal biochemical test results, thyroid function tests, blood count values and urine test results were statistically compared with exposure levels of mothers. It was found that the mothers exposed to HKB, p,p'-DDE, p,p'- DDT and o,p'-DDT, in addition these chemicals were transferred to the newborn baby with cord blood. A statistically significant difference was found between HKB and hemoglobin levels; p,p'-DDE and seafood consumption, alkaline phosphatase, potassium, triiodothyronine levels, percentage of hemoglobin concentration in erythrocytes, mean thrombocyte size; p,p′-DDT and creatinine levels and leukocyte number; o,p'-DDT level and type of birth and level of income (p<0.05). With these findings, we can conclude that OCPs effect certain health parameters of mothers and newborns.