Mı̇gren Hastalarında İnterosepsı̇yon Duyusunun İncelenmesi

Abstract

Gözde Özder, S. Examination of Interoception Sense in Migraine Patients, Hacettepe University Graduate School of Health Sciences, Neurology Physiotherapist Master's Thesis, Ankara, 2024. The purpose of this study; The purpose of this study is to examine the sense of interoception in migraine patients and to determine its relationship with changes in volumetric measurement of the insula. 30 healthy individuals and 55 migraine patients were included in the study. Demographic information of the participants and answers to the evaluations were recorded. The data was collected using the Multidimensinal Assesment of İnteroceptive Awareness-2 (MAIA-2), Toronto Alexithymia Scale-20 (TAS-20), Body Awareness Questionnaire (BAQ), Beck Depression Scale (BDI) and Beck Anxiety Scale (BAI), SF-36 Short Form Quality of Life Scale and the Pain Catastrophizing Scale (PCS). Additionally, to evaluate migraine-related disability in migraine patients, the Migraine Disability Assessment Scale (MIDAS) was used and insula volumes were measured from MRI images. It was determined that MAIA-2 scores (p=0,011), VFA values (p=0,520) and all subunit scores of SF-36 except emotional well-being and social function (p<0.05) were lower in migraine patients than in healthy individuals. However, TAS-20 score (p=0,018), PCS score (p=0,013) and BDI and BAI scores (p=0,003, p=0,001, respectively) were found to be higher in migraine patients. In migraine patients, a moderate positive correlation was observed between the MAIA-2 emotional awareness and body listening sub-scores and the frontal operculum volume of the right insula, and between the MAIA-2 trusting sub-score and the parietal operculum volume of the left insula (respectively r=0,528 p=0,024; r= 0,507, p=0,032; r=0,484, p=0,042). As a result, in our study, it was found that the sense of interoception was affected in migraine patients and that there was a relationship between interoception and the volume of the insula, which is one of the anatomical structures responsible for this sense.