Kafein Ve Glikoz Tüketiminin Prefrontal Korteks Aktivitesi ve Bilişsel Performans Üzerine Etkisi
Özet
Caffeine is a
psychoactive drug used to improve cognitive functions and is found in coffee,
chocolate, various drinks and many medical treatments. Glucose is the most common
dietary sugar in mammalian metabolism. Caffeine and glucose are used together in
various products, especially energy drinks. In our research, the effects of single and
combined consumption of caffeine and glucose on prefrontal cortex activity were
investigated. 40 healthy male volunteers participated in the study. Subjects were
examined in 4 groups: caffeine (200mg), glucose (25g), caffeine+glucose
(200mg+25g) and empty capsule. Verbal memory, Stroop and N-back tests were used
to compare cognitive performances. Prefrontal cortex activity during the tests was
recorded with the functional near infrared ray spectroscopy (fNIRS) method. The test
performances and fNIRS data of the subjects before and after taking the relevant
substance (caffeine, sugar, etc.) were evaluated separately between and within the
groups. As a result of the study, no effect of single or combined consumption of
caffeine and glucose on verbal memory was observed. A significant decrease in
reaction time was observed in subjects in the caffeine group due to caffeine
consumption, compared to their first performance without caffeine. Subjects in the
glucose group showed improvement in reaction time compared to their initial
performance only in the demanding working memory task condition. The
simultaneous consumption of caffeine and glucose had no effect on test
performance. When test performances were evaluated between groups, no group
showed a significant change compared to the control group. Hemodynamic activity
of the prefrontal cortex during tasks showed several differences between the
combined and individual consumption of caffeine and glucose.
