Açık Kalp Cerrahisi Uygulanan Hastalarda Preoperatif ve Postoperatif Cartılage Intermedıate Layer Proteın - 1 (Cılp1) Düzeylerinin Karşılaştırılması

Abstract

Studies conducted to treat and prevent heart failure have gained more importance. In studies to determine the degree of heart failure and to evaluate treatment response, it has been revealed that the CILP1 protein can be used to indicate pathological cardiac remodeling. In this study, we measured the serum levels of CILP1 protein before and after cardiopulmonary bypass (CPB), in patients who underwent open heart surgery. We revealed how postoperative CILP1 levels and changes in CILP1 levels are affected by CPB. We wanted to show whether CILP1 correlates with ejection fraction (EF), comorbidities, predictive scoring systems and postoperative outcomes. 41 patients with preserved EF and 32 patients with low EF were included in the study. CILP1 levels of the patients were measured at preoperative, postoperative 0, 24th and 72nd hours. It was found that the preoperative CILP1 level in patients with low EF was lower than the group of patients with preserved EF (p=0.002) and the change in CILP1 level over time was statistically significant (p<0.001), but it did not change according to patient groups. As the preoperative CILP1 level increased, EuroSCORE II (p=0.004) and BNP (p=0.013) levels were found to decrease, and there was a negative correlation between the preoperative CILP1 level and BNP measurements (p<0.05). It was shown that the percentage change in CILP1 level at the end of the 72nd hour after the operation decreased as the EF value increased (p=0.005), and decreased as the creatinine clearance level increased (p=0.048), and increased as the duration of CPB increased (p=0.029). It was found that the change in CILP1 levels before and after surgery was statistically significant in patients with no previous cardiac surgery (p<0.001). Postoperative CILP1 measurements can quantitatively determine the post-surgical myocardium status and contribute to personalized treatments for the patient.