Biyomedikal Uygulamalara Yönelik Olarak Fonksiyonel Polimerik Filmlerin Geliştirilmesi

Abstract

A large number of people around the world are affected by the number of injuries that occur every day for various reasons. Materials such as gauze and cotton used in the wound area cause prolongation of the healing process. Wound dressings, which accelerate the processes during wound healing and exhibit bioactive properties by showing a barrier effect, create superiority in the treatment processes. Within the scope of this thesis, it is aimed to develop a unique biomedical cover that can be applied in the form of a film consisting of natural materials with biocompatible and bioactive properties. For this purpose, biocompatible, biodegradable antibacterial chitosan with effect, quercetin with antioxidant properties and biocompatible, biodegradable hyaluronic acid were used. Chitosan-quercetin and chitosan-quercetin-hyaluronic acid formulations with different weight ratios of quercetin were prepared. Chemical characterizations of the developed biomedical films were made with Fourier Transform Infrared Spectrometer, thermal characterizations were made with Thermogravimetric Analysis and Differential Scanning Calorimetry. Within the scope of rheological studies, viscoelastic behavior was measured by measuring the shear rate against viscosity at constant temperature. The water contact angle and free surface energy measurement of the biomedical films were performed, and their swelling behavior and biodegradation properties were investigated. According to the results of the chemical characterizations, quercetin provided chemical bonding in hyaluronic acid containing and non containing formulations. The thermal characterization study showed that all formulations had good thermal stability for their intended use. Contact angle and surface free energy measurements showed that formulations containing hyaluronic acid were more hydrophobic than those without hyaluronic acid, and the polar component of surface free energy was lower. In rheological studies, samples showed non-newtonian fluid properties. The developed films showed high swelling capacity in aqueus media and biodegraded in lysozyme containing enzymatic media. As a result, novel films for biomedical applications have been successfully developed within the scope of this thesis. Due to the biocompatible, bioactive and antioxidant properties of the components, It is thought that the films will support the healing of the wound environment and may be a promising option as a wound dressing.