FARKLI ÜRETİM TEKNİKLERİYLE ÜRETİLEN PROTEZ KAİDE MATERYALLERİNDEN SALINAN REZİDÜEL MONOMER MİKTARININ KARŞILAŞTIRILMASI

Abstract

TEZCAN M. Comparison of the Amount of Residual Monomer Released from Denture Base Produced with Different Production Techniques Hacettepe University, Faculty of Dentistry, Thesis in Prosthodontics, Ankara, 2022. The use of three-dimensional printer technology is increasing rapidly in the dental field. This technology, also called additive manufacturing, which is in the category of computer aided production, is also used for the production of denture bases. During the polymerization of denture polymers, all monomers can’t participate in the reaction and some monomers are free in the polymer. Residual monomers may leak into the oral cavity and cause cytotoxic and allergic effects such as inflammation, irritation, and hypersensitivity. Before the delivery of the denture to the patient, different methods are applied to reduce the amount of residual monomer. The aim of this study is to compare the amount of residual monomer released in 1 day and 1 week seperately from heat-polymerized or 3D printed denture base materials applied different residual monomer amount reduction methods. A total of 192 polymer samples were produced with a 3D printer (n=96) and conventional method (n=96) according to user instructions. Both groups were divided into 4 different subgroups (n=24) for the residual monomer reduction methods to be applied. Each subgroup is divided into two, storage time for 1 day and 1 week. For the samples in the subgroups (n=24); residual monomer reduction methods were applied. Including no treatment (control), 5 minutes of ultrasonic (40kHz)with isopropyl alcohnol bath (99%), 24 hours of distilled water bath, 3 minutes of ethanol (99%) bath. High performance liquid chromatography method was applied to determine the amount of residual monomer released from polymer samples kept in 3ml 75% ethanol storage media for 1 day and 1 week separately. MMA and EGDMA released from conventional heat-cured total denture base samples, UDMA and TEGDMA monomers released from denture base samples produced with 3D printer were analyzed. Data were evaluated with Kruskal Wallis for residual monomer reduction methods. The Mann Whitney U test was applied between the groups that were kept for 1 day and 1 week in which the same residual monomer reduction method was applied. UDMA and TEGDMA monomer release amounts were found to be statistically significantly lower in the groups produced with a 3D printer, in the groups that were treated with an ultrasonic isopropyl alcohol bath for 5 minutes and ethanol (99%) bath for 3 minutes and kept for 1 day and 1 week compared to the control group (p <0.05). In the sample groups of heat polymerized base material, which is the conventional method, no difference was found in terms of residual monomer reduction methods (p>0.05). Isopropyl alcohol bath applied with ultrasonic or ethanol bath to the denture base material produced with a 3D printer significantly reduced the residual monomer release.

Keywords: residual monomer, additive manufacturing, denture base material, residual monomer reduction methods, high pressure liquid chromatography

Supported by H.Ü.B.A.K.B. Support Project (Project Code: TDH-2021-19291)