Psoriazis ve Periodontitisli Hastalarda Serum ve Dişeti Oluğu Sıvısında Yardımcı T Hücre 9/17/22 Sitokin Düzeylerinin Karşılaştırılması

Abstract

Psoriasis and periodontitis are immunologically mediated chronic inflammatory diseases that share common risk factors and associate with each other. Although the exact bidirectional causal relationship between the two has not yet been clearly established, interleukin (IL)-23/T helper (Th)17 pathway is thought to be involved in their common immunopathogenesis. This comparative, controlled and prospective clinical trial was designed to test the hypothesis that IL-9, IL-10, IL-17A, IL-21, IL-22, IL-23 and IL-27 can play a role in developing psoriasis and periodontal disease. Sample comprised the following groups: Psoriasis (+)/Periodontitis (+) (n=20), Psoriasis (+)/Periodontitis (–) (n=20), Psoriasis (–)/Periodontitis (+) (n=20), and Psoriasis (–)/Periodontitis (–) (n=20). Levels of serum and gingival crevicular fluid (GCF) IL-9, IL-10, IL-17A, IL-21, IL-22, IL-23 and IL-27 were determined by multiplex assay. The periodontal status of individuals was detected with periodontal clinical parameters consisted of number of teeth, probing depth, plaque index, gingival index, clinical attachment level and bleeding on probing. In addition, scraping of oral mucosa to detect candida species was done. No any statistically significant difference was found in prevalence of oral candidiasis between groups (p=0.214). Statistically significant high mean probing depth and clinical attachment level; low number of teeth and GCF IL-27 levels were found in the Psoriasis (+)/Periodontitis (+) group compared to Psoriasis (+)/Periodontitis (–) group (p<0.05, for all). Significantly high mean bleeding on probing and serum IL-23 levels was found in the Psoriasis (+)/Periodontitis (–) group compared to Psoriasis (–)/Periodontitis (–) group (p=0.021 and p=0.040). Statistically significant high serum IL-17A, IL-22, IL-23 levels and low serum IL-21, GCF IL-17A, IL-27 levels was found in the Psoriasis (+)/Periodontitis (+) group compared to Psoriasis (–)/Periodontitis (–) group (p<0.05, for all). In psoriasis patients, GCF IL-22 levels were negatively correlated with number of teeth and GCF IL-27 levels were negatively correlated with clinical attachment loss and probing depth (p<0.05, for all). Results show that, psoriasis patients suffer from worse periodontal health and IL-17A, IL-21, IL-22, IL-27 can play a role in psoriasis and periodontitis common immunopathogenesis. High serum IL-22 levels and low GCF IL-27 levels may help to determine the individuals who carry the risk of periodontitis in psoriasis patients.