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Investigating the Structural Influence of Surface Mutations on Acetylcholinesterase Inhibition by Organophosphorus Compounds and Oxime Reactivation

Kucukkilinc, Tuba; Cochran, Rory; Kalisiak, Jaroslaw; Garcia, Edzna; Valle, Anne; Amitai, Gabi; Radic, Zoran; Taylor, Palmer (Elsevier Ireland Ltd, 2010)

Organophosphates (OPs) exert their toxicity by inhibiting primarily acetylcholinesterase (AChE) and to a lesser extent butyrylcholinesterase (BChE). Binary mixtures of mammalian AChE and oximes of varying structure have ...