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dc.contributor.authorBajin, Inci Yaman
dc.contributor.authorDemir, Hulya
dc.contributor.authorTemizel, Inci Nur Saltik
dc.contributor.authorOzen, Hasan
dc.contributor.authorYuce, Aysel
dc.date.accessioned2021-06-02T10:39:50Z
dc.date.available2021-06-02T10:39:50Z
dc.date.issued2019
dc.identifier.issn0041-4301
dc.identifier.urihttp://dx.doi.org/10.24953/turkjped.2019.06.004
dc.identifier.urihttp://hdl.handle.net/11655/23824
dc.description.abstractChronic Hepatitis B infection is an important clinical issue because of the associated risk of developing cirrhosis and hepatocellular carcinoma. Especially in children, there is no consensus about the optimal treatment. Clinical features and long-term outcomes of 165 children diagnosed with chronic hepatitis B at our institution between January 1993 and June 2012 were analysed retrospectively. Patients were divided into four groups according to their treatment protocols. The first group received Interferon (IFN) only, the second group started lamivudine (LMV) first then IFN+LMV combined and then continued with LMV only, the third group started with IFN+LMV combined then continued with LMV only and the fourth group received LMV only. After a median follow-up period of 7 years (1-19 years) the highest e-seroconversion (the loss of HBeAg followed by gain of antiHBe antibody) rate, biochemical and virological response was observed with combined (IFN+LMV) treatment regimens. Patients with higher ALT levels were better treatment responders (p: 0.003). Identification of the patients who need to be treated in order to determine the most effective therapy with optimal treatment duration is important to reduce the risk of developing future complications like cirrhosis and hepatocellular carcinoma.
dc.language.isoen
dc.relation.isversionof10.24953/turkjped.2019.06.004
dc.rightsAttribution 4.0 United States
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectchildren
dc.subjectchronic hepatitis B
dc.subjecttreatment
dc.titleLong Term Follow-Up Of Children With Chronic Hepatitis B: A Single Center Experience
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalTurkish Journal Of Pediatrics
dc.contributor.departmentÇocuk Sağlığı ve Hastalıkları
dc.identifier.volume61
dc.identifier.issue6
dc.description.indexWoS
dc.description.indexScopus


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Attribution 4.0 United States
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