Ortopedik İmplantların Nanoteknolojik Yaklaşımlarla Fonksiyonelleştirilmesi

Abstract

In thesis study, surface modifications were carried out on titanium and titanium based alloys, which are used in orthopaedic implant and fixators, for the purpose of enhancing of the biocompatibility and bioactivity. New compositions in nano dimensions were obtained by performing anodic oxidation, apatitic calcium phosphate salt precipitation and electrospinning techniques one by one and/or consecutively. Ingrowing nanotubular spaces, nanocrystalline hydroxyapatite and collagen like silk fibroin nanofibers were successfully deposited on the titanium surfaces with anodic oxidation, simulated body fluid immersion and electrospinning, respectively. Physicochemical characterization of the obtained surfaces were carried out with scanning electron microscopy, infrared spectroscopy, water contact angle wettability and the surfaces were also tested with human osteoblast like Saos-2 cell type for biological aspects in terms of initial cell adhesion, cell proliferation, cell morphology, total protein synthesis, alkaline phosphatase activity and calcium deposition. Apart from modifications, the development of local drug releasing surfaces were planned for the prevention of post implantation bacterial infections. To eliminate the disadvantages of systemic toxicity or low effectivity on relevant sites of the oral and intravenous administration, drug releasing surfaces were developed with the use of nanotubular spaces with controllable aspect ratios, as drug reservoirs.