Kanamalı Hastalarda Klinik Özelliklerin Trombosit Fonksiyon Testleriyle Klinikopatolojik Korelasyonu
Özet
Özlem Beydaş, Clinicopathological Correlation of Clinical Features with Platelet Function Tests in Hemorrhagic Patients Hacettepe University Faculty of Medicine, Internal Medicine Specialization Thesis, ANKARA, 2020. Platelets are important in ensuring hemostasis. Platelet function disorders (PFD) include a large and heterogeneous group of bleeding disorders ranging from asymptomatic, mild to severe. One method in which PFD is evaluated is light transmission aggregometry (LTA). LTA is a system consisting of a light source, a mixing mechanism that enables sample mixing, a spectrophotometer, recorder and a computer that provides data analysis. With this method, a lot of information about platelet function and biochemistry can be obtained. LTA is frequently used worldwide in clinical practice and is still considered the gold standard. ISTH / SCC BAT is a standardized, quantitative Bleeding Assessment tool that can convert the severity of various bleeding symptoms into a summing bleeding score (BS). In this study, BS was calculated with this method. Between 01.08.2017-01.08.2019, the study was carried out with patients 18 years of age and older (18% male), whose LTA was studied at Hacettepe University Faculty of Medicine. Clinical and laboratory data previously determined were recorded in all patients. Data collected retrospectively were analyzed with appropriate statistical methods. PFD was present in 52 (46%) patients. PFD was present in 68.4% of patients with significant BS. In this study; It was observed that decreased aggregation with collagen alone affects the bleeding clinic and bleeding site. Bleeding localization was found to have a significant relationship with ADP (2 µM) and collagen. It was shown that nasal bleeding was significantly high in patients with an aggregation response with ADP-2 and decreased aggregation with ADP-2 in the majority of patients with menorrhagia. It was shown that LTA should be studied with ADP (2 µM) in patients with recurrent nasal bleeding, therefore, in which advanced treatment options such as electrocautilization are applied.