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dc.contributor.authorDemir, Nazlı
dc.contributor.authorAydın, Sevtap
dc.contributor.authorÜndeğer Bucurgat, Ülkü
dc.date.accessioned2020-02-13T11:47:34Z
dc.date.available2020-02-13T11:47:34Z
dc.date.issued2017
dc.identifier.issn1304-530X
dc.identifier.urihttps://doi.org/10.4274/tjps.79663
dc.identifier.urihttps://www.scopus.com/inward/record.url?eid=2-s2.0-85026676080&partnerID=40&md5=aca8639d235891d0a2adb1a729d8e054
dc.identifier.urihttp://hdl.handle.net/11655/22064
dc.description.abstractObjectives: Pendimethalin (N-(1-ethylpropyl)-3,4-dimethyl-2,6-dinitrobenzeneamine) is a dinitroaniline herbicide compound which selectively controls weeds. It is a cell division and growth inhibitor. It descends plants in a short time after seedling. It is a soil and water pollutant due to the widespread use of formulations in Turkey and around the world. Pendimethalin is manufactured in and imported by Turkey. Pendimethalin is a slightly toxic compound that is classified in toxicity class 3 by the United States Environmental Protection Agency (USEPA). Even though it is classified as group C (human possible carcinogen) compound by the USEPA, there are limited number of studies about its genotoxic effects. The aim of this study was to evaluate in vitro genotoxic effects of different concentrations of pendimethalin in Chinese hamster over (CHO) cells by the single cell gel electrophoresis (comet) assay. Materials and Methods: The cells are incubated with 1, 10, 100, 1000 and 10000 µM concentrations of pendimethalin for 30 min at 37°C and DNA damage was compared with CHO cells untreated with pendimethalin. 50 µM hydrogen peroxide was used as positive control. Results: No significant cytotoxic effects were observed within the concentration ranges studied. The DNA damage in CHO cells was significantly increased in the pendimethalin concentrations of 1, 100, 1000 and 10000 µM, however, a significant decrease was observed in 10 µM pendimethalin concentration. Conclusion: Our results show that 1-10000 µM concentrations of pendimethalin induce DNA damage in CHO cells, which was assessed by comet assay.tr_TR
dc.language.isoentr_TR
dc.publisherTurkish Pharmacists Associationtr_TR
dc.relation.isversionof10.4274/tjps.79663tr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectPendimethalintr_TR
dc.subjectHerbicidetr_TR
dc.subjectDNA damagetr_TR
dc.subjectComet assaytr_TR
dc.subjectCHO cellstr_TR
dc.subject.lcshEczacılıktr_TR
dc.titleAssessment Of Genotoxic Effects Of Pendimethalin In Chinese Hamster Over Cells By The Single Cell Gel Electrophoresis (Comet) Assaytr_TR
dc.title.alternativePendimetalinin Genotoksik Etkilerinin Çin Hamster Over Hücrelerinde Tek Hücre Jel Elektroforez (Comet) Yöntemiyle Değerlendirilmesitr_TR
dc.typeinfo:eu-repo/semantics/articletr_TR
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalTurkish Journal of Pharmaceutical Sciencestr_TR
dc.contributor.departmentFarmasötik Toksikolojitr_TR
dc.identifier.volume14tr_TR
dc.identifier.issue2tr_TR
dc.identifier.startpage185tr_TR
dc.identifier.endpage190tr_TR
dc.description.indexScopustr_TR
dc.fundingYoktr_TR


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