dc.contributor.author | Ergin, Alper | |
dc.contributor.author | Ercis, Serpil | |
dc.contributor.author | Hasçelik, Gülşen | |
dc.date.accessioned | 2020-01-28T10:45:16Z | |
dc.date.available | 2020-01-28T10:45:16Z | |
dc.date.issued | 2006 | |
dc.identifier.uri | https://doi.org/10.1093/jac/dki404 | |
dc.identifier.uri | https://www.scopus.com/inward/record.url?eid=2-s2.0-30344437587&partnerID=40&md5=b4ece1b5c67e158e4e1e45ea879e6fd0 | |
dc.identifier.uri | http://hdl.handle.net/11655/21895 | |
dc.description.abstract | Objectives: Our aim was to study the macrolide resistance mechanisms and antimicrobial susceptibilities
of viridans group streptococci (VGS) isolated from blood cultures.
Methods: In vitro susceptibilities to nine antimicrobials were studied for 85 VGS isolated from blood
cultures by agar dilution. Pheno- and genotyping of erythromycin-resistant isolates were studied by the
double disc test and PCR.
Results: Resistance to erythromycin was found in 27% (n = 23) of the isolates. Erythromycin-resistant
Streptococcus oralis (n = 13) predominated among the other erythromycin-resistant species isolated. The
phenotypes among 23 erythromycin-resistant isolates were as follows: 12 constitutive macrolide–
lincosamide–streptogramin (cMLSB) resistance phenotype and 11 macrolide (M) resistance phenotype.
Of the cMLSB isolates 11 had erm(B) genes and 11 of the M phenotype isolates had mef(A) genes. Four
of the cMLSB isolates had both erm(B) and mef(A) genes. None of the isolates had erm(TR) genes.
Combined resistance to erythromycin with penicillin, clindamycin, chloramphenicol, tetracycline and
quinupristin/dalfopristin was found in 100, 61, 74, 100 and 100% of the isolates, respectively. No resistance was found for vancomycin, linezolid and levofloxacin.
Conclusions: The macrolide resistance mechanisms of our VGS isolates revealed that the cMLSB
phenotype associated with erm(B) and the M phenotype associated with mef(A) genes are found with
similar frequencies. | tr_TR |
dc.language.iso | en | tr_TR |
dc.publisher | Oxford Univ Press | tr_TR |
dc.relation.isversionof | 10.1093/jac/dki404 | tr_TR |
dc.rights | info:eu-repo/semantics/openAccess | tr_TR |
dc.subject | Erythromycin resistance | tr_TR |
dc.subject | M phenotype | tr_TR |
dc.subject | S. oralis | tr_TR |
dc.subject | Erm(B) | tr_TR |
dc.subject | Mef(A) | tr_TR |
dc.subject.lcsh | Makrolid Antibiyotikler | tr_TR |
dc.title | Macrolide Resistance Mechanisms and in Vitro Susceptibility Patterns of Viridans Group Streptococci Isolated from Blood Cultures | tr_TR |
dc.type | info:eu-repo/semantics/article | tr_TR |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Journal of Antimicrobial Chemotherapy | tr_TR |
dc.contributor.department | Tıbbi Laboratuvar Teknikleri | tr_TR |
dc.identifier.volume | 57 | tr_TR |
dc.identifier.issue | 1 | tr_TR |
dc.identifier.startpage | 139 | tr_TR |
dc.identifier.endpage | 141 | tr_TR |
dc.description.index | Scopus | tr_TR |
dc.funding | Yok | tr_TR |