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dc.contributor.authorDemiralay, Ebru
dc.contributor.authorTepeoglu, Merih
dc.contributor.authorFidan, Cihan
dc.contributor.authorÜnal, Hakan Ümit
dc.contributor.authorKılıçkap, Saadettin
dc.date.accessioned2020-01-21T07:52:30Z
dc.date.available2020-01-21T07:52:30Z
dc.date.issued2013
dc.identifier.issn1513-7368
dc.identifier.urihttps://doi.org/10.7314/APJCP.2013.14.5.3151
dc.identifier.urihttp://hdl.handle.net/11655/21856
dc.description.abstractIntroduction: Colorectal cancers are in the top of the cancer-related causes of death in the world and lymph node metastasis is accepted as the primary prognostic factor. In this study, correlations of FGF19 staining pattern with local invasion and lymph node metastasis in a series of colorectal cancers were investigated. Methods: This studyincluded 81 colorectal cancer patients who underwent surgery in our hospital with no evidence of preoperative radiological distant metastasis. Routine pathological examination of the resection material was performed in order to identify vascular, perineural and serosal infiltration, regional lymph node metastasis and the degree of differentiation. Tumor tissue samples were stained with an immunohistochemistry method for FGF 19 evaluation and the staining pattern was statistically compared with the above mentioned characteristics of the tumors. Results: The patient population consisted of 47 females and 34 males with a median age of 70 years. In 40 patients regional lymph nodes were positive and 51%, 32% and 38% had serosal, perineural and vascular invasion. While 64 cases were moderately-differentiated, 11 cases were well-differentiated and 6 poorly-differentiated, there was no association with FGF 19 staining, including intensity. Conclusion: No evidence of significant statistically correlation was found between FGF 19 staining pattern and serosal, perineural, vascular invasion, lymph node involvement and degree of differentiation.tr_TR
dc.language.isoentr_TR
dc.publisherAsian Pacific Organization Cancer Preventiontr_TR
dc.relation.isversionof10.7314/APJCP.2013.14.5.3151tr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectColorectal cancertr_TR
dc.subjectFGF stainingtr_TR
dc.subjectLymph node metastasistr_TR
dc.subject.lcshKansertr_TR
dc.titleLack of Relationships Between Fgf19 Staining Pattern, Lymph Node Metastasis and Locally Invasive Characteristics of the Tumor in Colorectal Cancerstr_TR
dc.typeinfo:eu-repo/semantics/articletr_TR
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalAsian Pacific Journal Of Cancer Preventiontr_TR
dc.contributor.departmentTemel Onkolojitr_TR
dc.identifier.volume14tr_TR
dc.identifier.issue5tr_TR
dc.identifier.startpage3151tr_TR
dc.identifier.endpage3154tr_TR
dc.description.indexWoStr_TR
dc.description.indexScopustr_TR
dc.fundingYoktr_TR


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