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dc.contributor.authorJuranic, Nenad
dc.contributor.authorNemutlu, Emirhan
dc.contributor.authorZhang, Song
dc.contributor.authorDzeja, Petras
dc.contributor.authorTerzic, Andre
dc.contributor.authorMacura, Slobodan
dc.date.accessioned2019-12-16T10:29:32Z
dc.date.available2019-12-16T10:29:32Z
dc.date.issued2011
dc.identifier.issn0925-2738
dc.identifier.urihttps://doi.org/10.1007/s10858-011-9515-3
dc.identifier.urihttp://hdl.handle.net/11655/20135
dc.description.abstractIntramolecular correlations among the O-18-labels of metabolic oligophosphates, mapped by J-decoupled P-31 NMR 2D chemical shift correlation spectroscopy, impart stringent constraints to the O-18-isotope distributions over the whole oligophosphate moiety. The multiple deduced correlations of isotopic labels enable determination of site-specific fractional isotope enrichments and unravel the isotopologue statistics. This approach ensures accurate determination of O-18-labeling rates of phosphometabolites, critical in biochemical energy conversion and metabolic flux transmission. The biological usefulness of the J-decoupled P-31 NMR 2D chemical shift correlation maps was validated on adenosine tri-phosphate fractionally O-18 labeled in perfused mammalian hearts.
dc.language.isoen
dc.publisherSpringer
dc.relation.isversionof10.1007/s10858-011-9515-3
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiochemistry & Molecular Biology
dc.subjectSpectroscopy
dc.titleP-31 Nmr Correlation Maps Of O-18/O-16 Chemical Shift Isotopic Effects For Phosphometabolite Labeling Studies
dc.typeinfo:eu-repo/semantics/article
dc.relation.journalJournal Of Biomolecular Nmr
dc.contributor.departmentAnalitik Kimya
dc.identifier.volume50
dc.identifier.issue3
dc.identifier.startpage237
dc.identifier.endpage245
dc.description.indexWoS


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