| dc.contributor.author | Tandogan, Berivan | |
| dc.contributor.author | Ulusu, Nuray N. | |
| dc.date.accessioned | 2019-12-16T10:29:20Z | |
| dc.date.available | 2019-12-16T10:29:20Z | |
| dc.date.issued | 2006 | |
| dc.identifier.issn | 1475-6366 | |
| dc.identifier.uri | https://doi.org/10.1080/14756360500480533 | |
| dc.identifier.uri | http://hdl.handle.net/11655/20094 | |
| dc.description.abstract | Glucose-6-phosphate dehydrogenase (G-6-PD) is the first enzyme in the pentose phosphate pathway. Cadmium is a toxic heavy metal that inhibits several enzymes. Zinc is an essential metal but overdoses of zinc have toxic effects on enzyme activities. In this study G-6-PD from lamb kidney cortex was competitively inhibited by zinc both with respect to glucose-6-phosphate (G-6-P) and NADP(+) with Ki values of 1.066 +/- 0.106 and 0.111 +/- 0.007 mM respectively whereas cadmium was a non-competitive inhibitor with respect to both G-6-P and NADP+ Ki values of 2.028 +/- 0.175 and 2.044 +/- 0.289 mM respectively. | |
| dc.language.iso | en | |
| dc.publisher | Taylor & Francis Ltd | |
| dc.relation.isversionof | 10.1080/14756360500480533 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Biochemistry & Molecular Biology | |
| dc.subject | Pharmacology & Pharmacy | |
| dc.title | Effects Of Cadmium And Zinc Ions On Purified Lamb Kidney Cortex Glucose-6-Phosphate Dehydrogenase Activity | |
| dc.type | info:eu-repo/semantics/article | |
| dc.relation.journal | Journal Of Enzyme Inhibition And Medicinal Chemistry | |
| dc.contributor.department | Biyokimya | |
| dc.identifier.volume | 21 | |
| dc.identifier.issue | 2 | |
| dc.identifier.startpage | 225 | |
| dc.identifier.endpage | 230 | |
| dc.description.index | WoS | |
| dc.description.index | Scopus | |
