dc.contributor.author | Fan, CY | |
dc.contributor.author | Melhem, MF | |
dc.contributor.author | Hosal, AS | |
dc.contributor.author | Grandis, JR | |
dc.contributor.author | Barnes, EL | |
dc.date.accessioned | 2019-12-12T06:41:12Z | |
dc.date.available | 2019-12-12T06:41:12Z | |
dc.date.issued | 2001 | |
dc.identifier.issn | 0886-4470 | |
dc.identifier.uri | https://doi.org/10.1001/archotol.127.9.1075 | |
dc.identifier.uri | http://hdl.handle.net/11655/16649 | |
dc.description.abstract | Background: Salivary duct carcinoma (SDC) is a rare, highly aggressive neoplasm that primarily affects the major salivary glands. It is a distinct clinicopathological entity characterized by its morphologic resemblance to ductal carcinoma of the breast, a high incidence of regional lymph node metastasis, and distant dissemination. Frequent expression of androgen receptor (AR) but not estrogen receptor or progesterone receptor in SDCs suggests that SDC bears a close immunophenotypic homology with prostatic carcinoma. An AR-mediated autocrine growth pathway consisting of epidermal growth factor receptor (EGFR) and its ligand, transforming growth factor alpha (TGF-alpha), has been implicated in the carcinogenesis of prostatic carcinoma. Androgens, in the presence of AR, mediate their mitogenic effects on prostatic cancer cells by up-regulating the transcriptional and translational activities of EGFR and TGF-alpha. Through an autocrine mode of action, TGF-alpha produced in the tumor cells binds to its receptor, EGFR, which is also ex-pressed by these cells, resulting in a proliferative response. Objective: To investigate whether a TGF-alpha /EGFR autocrine pathway is present in SDCs. Design: Retrospective analysis of the expression of AR, EGFR, and TGF-alpha in 12 SDCs. Setting: An academic medical center. Results: Salivary duct carcinoma expresses AR, TGF-alpha, and EGFR in 11 (92%), 8 (67%), and 11 (92%) of 12 cases, respectively. Conclusion: An AR-mediated TGF-alpha /EGFR autocrine pathway may be implicated in the tumorigenesis of SDC. | |
dc.language.iso | en | |
dc.publisher | Amer Medical Assoc | |
dc.relation.isversionof | 10.1001/archotol.127.9.1075 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Otorhinolaryngology | |
dc.subject | Surgery | |
dc.title | Expression Of Androgen Receptor, Epidermal Growth Factor Receptor, And Transforming Growth Factor Alpha In Salivary Duct Carcinoma | tr_en |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:eu-repo/semantics/publishedVersion | |
dc.relation.journal | Archives Of Otolaryngology-Head & Neck Surgery | |
dc.contributor.department | Tıbbi Patoloji | |
dc.identifier.volume | 127 | |
dc.identifier.issue | 9 | |
dc.identifier.startpage | 1075 | |
dc.identifier.endpage | 1079 | |
dc.description.index | WoS | |