Basit öğe kaydını göster

dc.contributor.authorEsinler, Ibrahim
dc.contributor.authorAktas, Dilek
dc.contributor.authorOtegen, Umit
dc.contributor.authorAlikasifoglu, Mehmet
dc.contributor.authorYarali, Hakan
dc.contributor.authorTuncbilek, Ergul
dc.date.accessioned2019-12-12T06:40:28Z
dc.date.available2019-12-12T06:40:28Z
dc.date.issued2008
dc.identifier.issn1472-6483
dc.identifier.urihttps://doi.org/10.1016/S1472-6483(10)60596-2
dc.identifier.urihttp://hdl.handle.net/11655/16555
dc.description.abstractThe aim of this study was to assess the rates of variant alleles of cytochrome P4501A1 (CYP1A1) in patients with polycystic ovary syndrome (PCOS). It was designed as a case-control study in Hacettepe University, Faculty of Medicine, Department of Obstetrics and Gynecology and Genetics. Forty-eight patients with PCOS served as the study group. Ninety-six regularly cycling women with no clinical and biochemical evidence of hyperandrogenism and polycystic ovary appearance served as the controls. The CYP1A1 variant alleles of all patients were determined via polymerase chain reaction. The rate of the CYP1A1 isoleucine (Ile)/valine (Val) allele was significantly higher in patients with PCOS than in the controls (OR: 7.8, 95% CI: 3.45-17.52, P < 0.001). However, there was no statistically significant difference in the distribution of Val/Val genotype (OR: 4.0, 95% CI: , 0.60-26.73). The rate of any Val genotype (Ile/Val or Val/Val) was significantly higher in patients with PCOS compared with the control group (OR: 7.4, 95% CI: 3.33-16.46, P < 0.001). In conclusion, the patients with PCOS had a 7.8-fold higher frequency of CYP1A1 Ile/Val genotype and a 7.4-fold higher frequency of CYP1A1 of any Val genotype (Ile/Val or Val/Val).
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.isversionof10.1016/S1472-6483(10)60596-2
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectObstetrics & Gynecology
dc.subjectReproductive Biology
dc.titleCyp1A1 Gene Polymorphism And Polycystic Ovary Syndrome
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalReproductive Biomedicine Online
dc.contributor.departmentKadın Hastalıkları ve Doğum
dc.identifier.volume16
dc.identifier.issue3
dc.identifier.startpage356
dc.identifier.endpage360
dc.description.indexWoS
dc.description.indexScopus


Bu öğenin dosyaları:

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster