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dc.contributor.authorNeyisci, Cagri
dc.contributor.authorErdem, Yusuf
dc.contributor.authorBilekli, Ahmet Burak
dc.contributor.authorDemiralp, Bahtiyar
dc.contributor.authorKose, Ozkan
dc.contributor.authorBek, Dogan
dc.contributor.authorKorkusuz, Feza
dc.contributor.authorKankilic, Berna
dc.date.accessioned2019-12-10T11:32:27Z
dc.date.available2019-12-10T11:32:27Z
dc.date.issued2018
dc.identifier.issn2309-4990
dc.identifier.urihttps://doi.org/10.1177/2309499017754093
dc.identifier.urihttp://hdl.handle.net/11655/16032
dc.description.abstractIntroduction: The purpose of this present study is to investigate the efficacy of vancomycin-loaded VK100 silicone cement drug delivery system in the treatment of implant-related methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis in rats. Materials and Methods: Thirty-six adult (18-20 weeks old) female Sprague-Dawley rats were included in the study. All rats underwent experimental osteomyelitis surgery via injecting 100 mu L bacterial suspension of MRSA into the medullary canal. After a 2-week duration for the formation of osteomyelitis model, rats were assigned Introduction: randomly into four groups: control (C), systemic vancomycin (V), local vancomycin-loaded VK100 silicone cement (vVK100), and systemic vancomycin and local vancomycin-loaded VK100 silicone cement (V+vVK100). The following treatment protocols were administered to each group for 4 weeks. For group C, 0.9% saline solution equivalent to the volume of vancomycin dose (approximately 1 ml/kg) was administered intraperitoneally twice daily (12-h intervals). For group V, 15 mg/kg of vancomycin was administered intraperitoneally twice daily (12-h intervals). For group vVK100, vVK100 polymer was included so that the intramedullary canal of the rats are affected. For group V+vVK100, vVK100 polymer was included so that the intramedullary canal of the rats are affected and 15 mg/kg of vancomycin was administered intraperitoneally twice daily (12-h intervals). After 4 weeks of treatment, clinical, radiologic, microbiologic, and histopathologic evaluations were performed for all groups. Results: Results of this study revealed that all scores of the evaluation criteria for the treatment groups (groups V, vVK100, and V+vVK100) decreased due to the treatment protocols when compared to group C. These results show the effectiveness of all treatment protocols for the implant-related chronic MRSA osteomyelitis. However, there were no statistical difference between these three protocols. Conclusions: vVK100 polymer, as a local antibiotic delivery system, seems to be an effective method for the treatment of implant-related chronic MRSA osteomyelitis.
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.isversionof10.1177/2309499017754093
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOrthopedics
dc.subjectSurgery
dc.titleTreatment Of Implant-Related Methicillin-Resistant Staphylococcus Aureus Osteomyelitis With Vancomycin-Loaded Vk100 Silicone Cement: An Experimental Study In Rats
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.relation.journalJournal Of Orthopaedic Surgery
dc.contributor.departmentSpor Hekimliği
dc.identifier.volume26
dc.identifier.issue1
dc.description.indexWoS
dc.description.indexScopus


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